Expression of MAGE-A4 and MAGE-C1 tumor-associated antigen in benign and malignant thyroid diseases.

Authors :: Melo DH
Mamede RC
Neder L
Saggioro FP
Figueiredo DL
da Silva WA Jr
Jungbluth AA
Zago MA
Source :: Head & neck [Head Neck] 2011 Oct; Vol. 33 (10), pp. 1426-32. Date of Electronic Publication: 2011 Jan 18.
Publication Year :: 2011
Abstract: Background: A subset of thyroid tumors characterized by a follicular growth pattern can represent a serious diagnosis. Immunohistochemistry and molecular pathology for genetic profiling have been used in an attempt to resolve some of these issues.<br />Methods: Tumor tissue samples of thyroid were obtained from 70 patients who underwent surgical therapy. They were divided into 4 groups: 20 adenomatous goiters, 10 follicular adenomas, 24 papillary carcinomas, and 16 follicular carcinomas. Immunohistochemical analysis was carried out using antibodies for MAGE-A4 (melanoma antigen-encoding gene A4) and MAGE-C1 (melanoma antigen-encoding gene C1).<br />Results: Standard histologic analysis and immunohistochemistry analysis of MAGE-A4 and MAGE-C1 expression were performed in all patients. The antigens examined were not expressed in any of the tissues.<br />Conclusions: The malignant degeneration of normal tissues is a multifactorial process, varying considerably both among tumor types and among individual patients. The present study showed that there was no immunolabeling of the MAGE-A4 and MAGE-C1 antigens.<br /> (Copyright © 2011 Wiley Periodicals, Inc.)

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