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Design, synthesis, and biological evaluation of a biyouyanagin compound library.
- Source :
-
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2011 Apr 26; Vol. 108 (17), pp. 6715-20. Date of Electronic Publication: 2011 Jan 18. - Publication Year :
- 2011
-
Abstract
- Modern drug discovery efforts rely, to a large extent, on lead compounds from two classes of small organic molecules; namely, natural products (i.e., secondary metabolites) and designed compounds (i.e., synthetic molecules). In this article, we demonstrate how these two domains of lead compounds can be merged through total synthesis and molecular design of analogs patterned after the targeted natural products, whose promising biological properties provide the motivation. Specifically, the present study targeted the naturally occurring biyouyanagins A and B and their analogs through modular chemical synthesis and led to the discovery of small organic molecules possessing anti-HIV and anti-arenavirus properties.
- Subjects :
- Anti-HIV Agents chemistry
Anti-HIV Agents pharmacology
Arenaviridae Infections drug therapy
Cell Line
HIV Infections drug therapy
Humans
Molecular Structure
Sesquiterpenes pharmacology
Spiro Compounds pharmacology
Anti-HIV Agents chemical synthesis
Arenavirus
HIV
Sesquiterpenes chemical synthesis
Sesquiterpenes chemistry
Spiro Compounds chemical synthesis
Spiro Compounds chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1091-6490
- Volume :
- 108
- Issue :
- 17
- Database :
- MEDLINE
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Academic Journal
- Accession number :
- 21245351
- Full Text :
- https://doi.org/10.1073/pnas.1015258108