Energy matters: mitochondrial proteomics for biomedicine.

Authors :: Gianazza E
Eberini I
Sensi C
Barile M
Vergani L
Vanoni MA
Source :: Proteomics [Proteomics] 2011 Feb; Vol. 11 (4), pp. 657-74. Date of Electronic Publication: 2011 Jan 17.
Publication Year :: 2011
Abstract: This review compiles results of medical relevance from mitochondrial proteomics, grouped either according to the type of disease - genetic or degenerative - or to the involved mechanism - oxidative stress or apoptosis. The findings are commented in the light of our current understanding of uniformity/variability in cell responses to different stimuli. Specificities in the conceptual and technical approaches to human mitochondrial proteomics are also outlined.<br /> (Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)