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Mortality of one-week-old chickens during naturally occurring Marek's disease virus infection.
- Source :
-
Veterinary pathology [Vet Pathol] 2011 Sep; Vol. 48 (5), pp. 993-8. Date of Electronic Publication: 2011 Jan 14. - Publication Year :
- 2011
-
Abstract
- Marek's disease (MD) is a disease of chickens that occurs worldwide and has serious economic consequences. MD can present as one of several forms, with the most commonly occurring forms being the lymphoproliferative diseases. Under experimental conditions, an early mortality syndrome has been recognized following infection by some but not all strains of MD virus (MDV). This is the first report of a confirmed case of mortality due to naturally occurring MDV infection in 1-week-old, nonvaccinated, chickens. Necrotizing lesions were observed in the bursa of Fabricius, lung, duodenum, jejunum, and proventriculus, and large intranuclear inclusion bodies were a striking feature in tissues with lesions in all birds. Immunohistochemical staining for the pp38 protein of MDV revealed abundant pp38 antigen in the affected tissues, confirming the presence of MDV within the lesions. PCR yielded an amplicon with 97% homology to the meq gene of MDV. No evidence of co-infection by either of the immunosuppressive agents chicken anemia virus and infectious bursal disease virus was detected.
- Subjects :
- Animals
Antigens, Viral analysis
DNA, Viral chemistry
DNA, Viral genetics
Herpesvirus 2, Gallid genetics
Immunohistochemistry veterinary
Marek Disease mortality
Marek Disease pathology
Polymerase Chain Reaction veterinary
Chickens
Herpesvirus 2, Gallid isolation & purification
Marek Disease virology
Subjects
Details
- Language :
- English
- ISSN :
- 1544-2217
- Volume :
- 48
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Veterinary pathology
- Publication Type :
- Academic Journal
- Accession number :
- 21239693
- Full Text :
- https://doi.org/10.1177/0300985810395727