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Stimulation by a TRH precursor, TRH-Gly, of TSH and PRL secretion in rats: effect of starvation.
- Source :
-
Neuropeptides [Neuropeptides] 1990 Jun; Vol. 16 (2), pp. 57-62. - Publication Year :
- 1990
-
Abstract
- The hypophysial activities of a possible direct precursor of thyrotropin (TSH)-releasing hormone (TRH), TRH-Gly, were evaluated in estrogen, progesterone-primed rats under urethane anesthesia. Intravenous administration of TRH-Gly in doses of 2-200 micrograms caused a significant and dose-dependent increase in blood TSH and prolactin (PRL). The stimulatory activity of TRH-Gly was 170 to 400-times less potent than that of TRH. The lower potency was confirmed by the action of TRH-Gly on the anterior pituitary cells in vitro. In starved rats, TRH-Gly apparently stimulated TSH and PRL secretion in a dose-dependent manner, and the stimulatory activity increased in starved rats as compared to normal controls. TRH-Gly did not affect [3H-MeHis]TRH binding in pituitary plasma membranes. These data imply that large amounts of TRH-Gly may have significant biological activities and these are potentiated in the starved condition.
- Subjects :
- Animals
Chromatography, High Pressure Liquid
Male
Pituitary Gland, Anterior cytology
Pituitary Gland, Anterior metabolism
Prolactin blood
Rats
Rats, Inbred Strains
Starvation blood
Thyrotropin blood
Prodrugs pharmacology
Prolactin metabolism
Starvation metabolism
Thyrotropin metabolism
Thyrotropin-Releasing Hormone pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0143-4179
- Volume :
- 16
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Neuropeptides
- Publication Type :
- Academic Journal
- Accession number :
- 2123526
- Full Text :
- https://doi.org/10.1016/0143-4179(90)90112-c