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Synthesis and pharmacological activities of 6-glycine substituted 14-phenylpropoxymorphinans, a novel class of opioids with high opioid receptor affinities and antinociceptive potencies.
- Source :
-
Journal of medicinal chemistry [J Med Chem] 2011 Feb 24; Vol. 54 (4), pp. 980-8. Date of Electronic Publication: 2011 Jan 14. - Publication Year :
- 2011
-
Abstract
- The synthesis and the effect of a combination of 6-glycine and 14-phenylpropoxy substitutions in N-methyl- and N-cycloproplymethylmorphinans on biological activities are described. Binding studies revealed that all new 14-phenylpropoxymorphinans (11-18) displayed high affinity to opioid receptors. Replacement of the 14-methoxy group with a phenylpropoxy group led to an enhancement in affinity to all three opioid receptor types, with most pronounced increases in δ and κ activities, hence resulting in a loss of μ receptor selectivity. All compounds (11-18) showed potent and long-lasting antinociceptive effects in the tail-flick test in rats after subcutaneous administration. For the N-methyl derivatives 13 and 14, analgesic potencies were in the range of their 14-methoxy analogues 9 and 10, respectively. Even derivatives 15-18 with an N-cyclopropylmethyl substituent acted as potent antinociceptive agents, being several fold more potent than morphine. Subcutaneous administration of compounds 13 and 14 produced significant and prolonged antinociceptive effects mediated through peripheral opioid mechanisms in carrageenan-induced inflammatory hyperalgesia in rats.
- Subjects :
- Analgesics chemistry
Animals
Binding, Competitive
Guanosine 5'-O-(3-Thiotriphosphate) metabolism
Magnetic Resonance Spectroscopy
Morphinans chemistry
N-substituted Glycines chemistry
Pain drug therapy
Rats
Spectrometry, Mass, Electrospray Ionization
Spectroscopy, Fourier Transform Infrared
Structure-Activity Relationship
Analgesics chemical synthesis
Analgesics pharmacology
Morphinans chemical synthesis
Morphinans pharmacology
N-substituted Glycines chemical synthesis
N-substituted Glycines pharmacology
Receptors, Opioid metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1520-4804
- Volume :
- 54
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 21235243
- Full Text :
- https://doi.org/10.1021/jm101211p