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Evaluation of PMI-5011, an ethanolic extract of Artemisia dracunculus L., on peripheral neuropathy in streptozotocin-diabetic mice.

Authors :
Watcho P
Stavniichuk R
Tane P
Shevalye H
Maksimchyk Y
Pacher P
Obrosova IG
Source :
International journal of molecular medicine [Int J Mol Med] 2011 Mar; Vol. 27 (3), pp. 299-307. Date of Electronic Publication: 2011 Jan 11.
Publication Year :
2011

Abstract

We previously reported that PMI-5011, an ethanolic extract of Artemisia dracunculus L., alleviates peripheral neuropathy in high fat diet-fed mice, a model of prediabetes and obesity developing oxidative stress and pro-inflammatory changes in the peripheral nervous system. This study evaluated PMI-5011 on established functional, structural, and biochemical changes associated with Type I diabetic peripheral neuropathy. C57Bl6/J mice with streptozotocin-induced diabetes of a 12-week duration, developed motor and sensory nerve conduction velocity deficits, thermal and mechanical hypoalgesia, tactile allodynia, and intra-epidermal nerve fiber loss. PMI-5011 (500 mg/kg/day for 7 weeks) alleviated diabetes-induced nerve conduction slowing, small sensory nerve fiber dysfunction, and increased intra-epidermal nerve fiber density. PMI-5011 blunted sciatic nerve and spinal cord 12/15-lipoxygenase activation and oxidative-nitrosative stress, without ameliorating hyperglycemia or reducing sciatic nerve sorbitol pathway intermediate accumulation. In conclusion, PMI-5011, a safe and non-toxic botanical extract, may find use in the treatment of diabetic peripheral neuropathy.

Details

Language :
English
ISSN :
1791-244X
Volume :
27
Issue :
3
Database :
MEDLINE
Journal :
International journal of molecular medicine
Publication Type :
Academic Journal
Accession number :
21225225
Full Text :
https://doi.org/10.3892/ijmm.2011.597