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Evaluation of PMI-5011, an ethanolic extract of Artemisia dracunculus L., on peripheral neuropathy in streptozotocin-diabetic mice.
- Source :
-
International journal of molecular medicine [Int J Mol Med] 2011 Mar; Vol. 27 (3), pp. 299-307. Date of Electronic Publication: 2011 Jan 11. - Publication Year :
- 2011
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Abstract
- We previously reported that PMI-5011, an ethanolic extract of Artemisia dracunculus L., alleviates peripheral neuropathy in high fat diet-fed mice, a model of prediabetes and obesity developing oxidative stress and pro-inflammatory changes in the peripheral nervous system. This study evaluated PMI-5011 on established functional, structural, and biochemical changes associated with Type I diabetic peripheral neuropathy. C57Bl6/J mice with streptozotocin-induced diabetes of a 12-week duration, developed motor and sensory nerve conduction velocity deficits, thermal and mechanical hypoalgesia, tactile allodynia, and intra-epidermal nerve fiber loss. PMI-5011 (500 mg/kg/day for 7 weeks) alleviated diabetes-induced nerve conduction slowing, small sensory nerve fiber dysfunction, and increased intra-epidermal nerve fiber density. PMI-5011 blunted sciatic nerve and spinal cord 12/15-lipoxygenase activation and oxidative-nitrosative stress, without ameliorating hyperglycemia or reducing sciatic nerve sorbitol pathway intermediate accumulation. In conclusion, PMI-5011, a safe and non-toxic botanical extract, may find use in the treatment of diabetic peripheral neuropathy.
- Subjects :
- Animals
Diabetes Mellitus, Experimental metabolism
Diabetes Mellitus, Experimental pathology
Diabetes Mellitus, Experimental physiopathology
Diabetic Nephropathies metabolism
Diabetic Nephropathies pathology
Diabetic Nephropathies physiopathology
Dietary Fats administration & dosage
Dietary Fats adverse effects
Epidermis metabolism
Epidermis pathology
Epidermis physiopathology
Hyperalgesia drug therapy
Hyperalgesia metabolism
Hyperalgesia pathology
Hyperalgesia physiopathology
Hyperglycemia metabolism
Hyperglycemia pathology
Hyperglycemia physiopathology
Lipoxygenase metabolism
Mice
Nerve Tissue Proteins metabolism
Plant Extracts chemistry
Sciatic Nerve metabolism
Sciatic Nerve pathology
Sciatic Nerve physiopathology
Spinal Cord metabolism
Spinal Cord pathology
Spinal Cord physiopathology
Artemisia chemistry
Diabetes Mellitus, Experimental drug therapy
Diabetic Nephropathies drug therapy
Epidermis innervation
Oxidative Stress drug effects
Phytotherapy
Plant Extracts pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1791-244X
- Volume :
- 27
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- International journal of molecular medicine
- Publication Type :
- Academic Journal
- Accession number :
- 21225225
- Full Text :
- https://doi.org/10.3892/ijmm.2011.597