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Functional sympatholysis is impaired in hypertensive humans.
- Source :
-
The Journal of physiology [J Physiol] 2011 Mar 01; Vol. 589 (Pt 5), pp. 1209-20. Date of Electronic Publication: 2011 Jan 04. - Publication Year :
- 2011
-
Abstract
- In healthy individuals, sympathetic vasoconstriction is markedly blunted in exercising muscles to optimize blood flow to the metabolically active muscle fibres. This protective mechanism, termed functional sympatholysis, is impaired in rat models of angiotensin-dependent hypertension. However, the relevance of these findings to human hypertension is unknown. Therefore, in 13 hypertensive and 17 normotensive subjects we measured muscle oxygenation and forearm blood flow (FBF) responses to reflex increases in sympathetic nerve activity (SNA) evoked by lower body negative pressure (LBNP) at rest and during moderate-intensity rhythmic handgrip exercise. In the normotensives, LBNP caused decreases in oxygenation and FBF (−16 ± 2% and −23 ± 4%, respectively) in resting forearm but not in exercising forearm (−1 ± 2% and −1 ± 3%, respectively; P < 0.05 vs. rest). In the hypertensives, LBNP evoked decreases in oxygenation and FBF that were similar in the resting and exercising forearm (−14 ± 2% vs. −12 ± 2% and −20 ± 3% vs. −13 ± 2%, respectively; P > 0.05), indicating impaired functional sympatholysis. In the hypertensives, SNA was unexpectedly increased by 54 ± 11% during handgrip alone. However, when SNA was experimentally increased during exercise in the normotensives, sympatholysis was unaffected. Treatment for 4 weeks with the angiotensin receptor blocker irbesartan, but not with the thiazide-type diuretic chlorthalidone, restored sympatholysis in the hypertensives. These data provide the first evidence that functional sympatholysis is impaired in hypertensive humans by a mechanism that appears to involve an angiotensin-dependent increase in sympathetic vasoconstriction in the exercising muscles.
- Subjects :
- Adult
Angiotensin II Type 1 Receptor Blockers pharmacology
Biphenyl Compounds pharmacology
Blood Pressure drug effects
Electrocardiography
Female
Hand Strength physiology
Heart Rate drug effects
Heart Rate physiology
Humans
Irbesartan
Lower Body Negative Pressure
Male
Middle Aged
Muscle Contraction physiology
Muscle, Skeletal blood supply
Muscle, Skeletal drug effects
Muscle, Skeletal physiopathology
Oxygen Consumption drug effects
Regional Blood Flow drug effects
Sympathetic Nervous System drug effects
Tetrazoles pharmacology
Vasoconstriction drug effects
Vasoconstriction physiology
Blood Pressure physiology
Forearm blood supply
Hypertension physiopathology
Oxygen Consumption physiology
Regional Blood Flow physiology
Sympathetic Nervous System physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1469-7793
- Volume :
- 589
- Issue :
- Pt 5
- Database :
- MEDLINE
- Journal :
- The Journal of physiology
- Publication Type :
- Academic Journal
- Accession number :
- 21224235
- Full Text :
- https://doi.org/10.1113/jphysiol.2010.203026