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Salivary gland progenitor cell biology provides a rationale for therapeutic salivary gland regeneration.
- Source :
-
Oral diseases [Oral Dis] 2011 Jul; Vol. 17 (5), pp. 445-9. Date of Electronic Publication: 2011 Jan 11. - Publication Year :
- 2011
-
Abstract
- An irreversible loss of salivary gland function often occurs in humans after removal of salivary tumors, after therapeutic radiation of head and neck tumors, as a result of Sjögren's syndrome and in genetic syndromes affecting gland development. The permanent loss of gland function impairs the oral health of these patients and broadly affects their quality of life. The regeneration of functional salivary gland tissue is thus an important therapeutic goal for the field of regenerative medicine and will likely involve stem/progenitor cell biology and/or tissue engineering approaches. Recent reports demonstrate how both innervation of the salivary gland epithelium and certain growth factors influence progenitor cell growth during mouse salivary gland development. These advances in our understanding suggest that developmental mechanisms of mouse salivary gland development may provide a paradigm for postnatal regeneration of both mice and human salivary glands. Herein, we will discuss the developmental mechanisms that influence progenitor cell biology and the implications for salivary gland regeneration.<br /> (© 2011 John Wiley & Sons A/S.)
- Subjects :
- Animals
Cell Lineage
Disease Models, Animal
Epithelial Cells physiology
Ganglia, Parasympathetic growth & development
Humans
Intercellular Signaling Peptides and Proteins physiology
Mice
Salivary Ducts cytology
Salivary Glands physiology
Stem Cells classification
Submandibular Gland innervation
Tissue Engineering
Regeneration physiology
Salivary Gland Diseases therapy
Salivary Glands cytology
Stem Cells physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1601-0825
- Volume :
- 17
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Oral diseases
- Publication Type :
- Academic Journal
- Accession number :
- 21223454
- Full Text :
- https://doi.org/10.1111/j.1601-0825.2010.01783.x