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Roles and mechanisms of microRNAs in pancreatic cancer.

Authors :
Zhang L
Jamaluddin MS
Weakley SM
Yao Q
Chen C
Source :
World journal of surgery [World J Surg] 2011 Aug; Vol. 35 (8), pp. 1725-31.
Publication Year :
2011

Abstract

Pancreatic cancer (PC) is an aggressive malignancy with poor survival. The discovery of microRNAs (miRNAs) has provided a new opportunity to study the disease. Thus far, altered expression of miRNAs has been reported in a wide range of malignancies, including PC, and some miRNAs are associated with PC cell proliferation, invasion, chemoresistance, and patient survival. This review summarizes recent advances with respect to the roles and mechanisms of miRNAs in PC and discusses potential clinical applications.

Details

Language :
English
ISSN :
1432-2323
Volume :
35
Issue :
8
Database :
MEDLINE
Journal :
World journal of surgery
Publication Type :
Academic Journal
Accession number :
21222121
Full Text :
https://doi.org/10.1007/s00268-010-0952-z