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The association between maternal glucose concentration and child BMI at age 3 years.
- Source :
-
Diabetes care [Diabetes Care] 2011 Feb; Vol. 34 (2), pp. 480-4. Date of Electronic Publication: 2011 Jan 07. - Publication Year :
- 2011
-
Abstract
- Objective: The objective of the study was to determine the association between child BMI at age 3 years and maternal glucose concentration among women without pre-existing diabetes or a gestational diabetes mellitus (GDM) diagnosis.<br />Research Design and Methods: Data are from the Pregnancy Infection and Nutrition and Postpartum studies and include 263 mother-child pairs. Measured weights and heights at 3 years were used to calculate age- and sex-specific BMI z scores and percentiles. Multivariable linear regression models were used to examine associations of continuous BMI z scores with maternal glucose concentration. Modified Poisson regression estimated risk ratios of child overweight/obesity (BMI ≥ 85th percentile).<br />Results: The mean (SD) maternal glucose concentration and prepregnancy BMI were 103.8 (23.7) mg/dL and 24.3 (5.9) kg/m(2), respectively. At 3 years, the mean (SD) child BMI z score was 0.29 (0.99), 20.9% were overweight/obese and 5.3% were obese. In the adjusted model, when compared with glucose concentration <100 mg/dL, a concentration ≥ 130 mg/dL was associated with significantly higher child BMI z score at 3 years (estimated z score difference of 0.39 [95% CI: 0.03-0.75]). With the use of the same reference category, a concentration ≥ 130 mg/dL was associated with an approximate twofold greater risk of child overweight/obesity (adjusted risk ratio 2.34 [95% CI: 1.25-4.38]).<br />Conclusions: Fetal exposure to high maternal glucose concentration in the absence of pre-existing diabetes or GDM may contribute to the development of overweight/obesity in the offspring, independent of maternal prepregnancy BMI.
- Subjects :
- Child, Preschool
Female
Glucose Intolerance epidemiology
Humans
Longitudinal Studies
Male
Mothers
Obesity epidemiology
Predictive Value of Tests
Pregnancy
Prenatal Exposure Delayed Effects epidemiology
Prospective Studies
Risk Factors
Blood Glucose metabolism
Body Mass Index
Glucose Intolerance metabolism
Obesity metabolism
Prenatal Exposure Delayed Effects metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1935-5548
- Volume :
- 34
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Diabetes care
- Publication Type :
- Academic Journal
- Accession number :
- 21216858
- Full Text :
- https://doi.org/10.2337/dc10-1766