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Targeted human serum albumin nanoparticles for specific uptake in EGFR-Expressing colon carcinoma cells.
- Source :
-
Nanomedicine : nanotechnology, biology, and medicine [Nanomedicine] 2011 Aug; Vol. 7 (4), pp. 454-63. Date of Electronic Publication: 2011 Jan 05. - Publication Year :
- 2011
-
Abstract
- The specific application and transport of drugs into malignant tissue is a critical point during diagnosis and therapy. Nanoparticles are known as excellent drug carrier systems and offer the possibility of surface modification with targeting ligands, leading to a specific accumulation in the targeted tissue. First, the specificity of such a carrier system has to be proven. In this study, cetuximab-modified nanoparticles based on biodegradable human serum albumin (HSA) are investigated regarding their cellular binding and intracellular accumulation. Different EGFR-expressing colon carcinoma cells were used to test possible cytotoxic potential, specific binding and intracellular accumulation. A specific accumulation targeting the EGFR could be shown. These results emphasize that cetuximab-modified HSA-nanoparticles are a promising carrier system for later drug transport. To our knowledge, this is the first study investigating the specific accumulation of HSA nanoparticles into different EGFR-expressing colon carcinoma cells.<br />From the Clinical Editor: In this study, cetuximab-modified nanoparticles based on human serum albumin (HSA) are investigated regarding their cellular binding and intracellular accumulation. The results suggest that these nanoparticles are a promising carrier system for EGFR overexpressing colon carcinoma cells.<br /> (Copyright © 2011 Elsevier Inc. All rights reserved.)
- Subjects :
- Antibodies, Monoclonal administration & dosage
Antibodies, Monoclonal, Humanized
Antineoplastic Agents pharmacology
Cell Line, Tumor
Cell Survival drug effects
Cetuximab
Humans
Nanoparticles administration & dosage
Antibodies, Monoclonal chemistry
Antineoplastic Agents chemistry
Colonic Neoplasms metabolism
ErbB Receptors antagonists & inhibitors
Nanoparticles chemistry
Nanotechnology methods
Serum Albumin chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1549-9642
- Volume :
- 7
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Nanomedicine : nanotechnology, biology, and medicine
- Publication Type :
- Academic Journal
- Accession number :
- 21215330
- Full Text :
- https://doi.org/10.1016/j.nano.2010.12.003