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Targeted human serum albumin nanoparticles for specific uptake in EGFR-Expressing colon carcinoma cells.

Authors :
Löw K
Wacker M
Wagner S
Langer K
von Briesen H
Source :
Nanomedicine : nanotechnology, biology, and medicine [Nanomedicine] 2011 Aug; Vol. 7 (4), pp. 454-63. Date of Electronic Publication: 2011 Jan 05.
Publication Year :
2011

Abstract

The specific application and transport of drugs into malignant tissue is a critical point during diagnosis and therapy. Nanoparticles are known as excellent drug carrier systems and offer the possibility of surface modification with targeting ligands, leading to a specific accumulation in the targeted tissue. First, the specificity of such a carrier system has to be proven. In this study, cetuximab-modified nanoparticles based on biodegradable human serum albumin (HSA) are investigated regarding their cellular binding and intracellular accumulation. Different EGFR-expressing colon carcinoma cells were used to test possible cytotoxic potential, specific binding and intracellular accumulation. A specific accumulation targeting the EGFR could be shown. These results emphasize that cetuximab-modified HSA-nanoparticles are a promising carrier system for later drug transport. To our knowledge, this is the first study investigating the specific accumulation of HSA nanoparticles into different EGFR-expressing colon carcinoma cells.<br />From the Clinical Editor: In this study, cetuximab-modified nanoparticles based on human serum albumin (HSA) are investigated regarding their cellular binding and intracellular accumulation. The results suggest that these nanoparticles are a promising carrier system for EGFR overexpressing colon carcinoma cells.<br /> (Copyright © 2011 Elsevier Inc. All rights reserved.)

Details

Language :
English
ISSN :
1549-9642
Volume :
7
Issue :
4
Database :
MEDLINE
Journal :
Nanomedicine : nanotechnology, biology, and medicine
Publication Type :
Academic Journal
Accession number :
21215330
Full Text :
https://doi.org/10.1016/j.nano.2010.12.003