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Severe tricuspid regurgitation in a patient receiving low-dose cabergoline for the treatment of acromegaly.
- Source :
-
The Journal of heart valve disease [J Heart Valve Dis] 2010 Nov; Vol. 19 (6), pp. 797-800. - Publication Year :
- 2010
-
Abstract
- Cabergoline, an ergot-derived dopamine receptor agonist, is used widely in the treatment of Parkinson's disease (PD) and hyperprolactinemia, but may cause heart valve fibrosis, retraction, and clinically significant regurgitation in PD patients. While cabergoline has been used at much lower doses in patients with hyperprolactinemia, controversy persists as to whether it may cause heart valve disease in this situation. Cabergoline is also used in acromegaly at doses similar to those used in hyperprolactinemia. The case is reported of a female patient with acromegaly who had been taking low-dose (0.5 mg/day) cabergoline for one year, and presented with signs and symptoms of right-sided heart failure. Echocardiography revealed a thickened and retracted tricuspid valve associated with severe tricuspid regurgitation and enlargement of the right-heart chambers. The morphology of the tricuspid valve was typical for cabergoline-related valvulopathy. Cabergoline may not be totally safe even at lower doses, and close echocardiographic monitoring is recommended in patients receiving cabergoline treatment, regardless of the dose level employed.
- Subjects :
- Cabergoline
Diuretics
Echocardiography, Doppler, Color
Ergolines administration & dosage
Female
Furosemide therapeutic use
Heart Failure chemically induced
Hormone Antagonists administration & dosage
Humans
Middle Aged
Severity of Illness Index
Treatment Outcome
Tricuspid Valve Insufficiency diagnostic imaging
Tricuspid Valve Insufficiency drug therapy
Acromegaly drug therapy
Ergolines adverse effects
Hormone Antagonists adverse effects
Tricuspid Valve Insufficiency chemically induced
Subjects
Details
- Language :
- English
- ISSN :
- 0966-8519
- Volume :
- 19
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- The Journal of heart valve disease
- Publication Type :
- Academic Journal
- Accession number :
- 21214109