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[Expression of NF-kappa B and AP-1 in non-small cell lung cancer].
- Source :
-
Zhongguo fei ai za zhi = Chinese journal of lung cancer [Zhongguo Fei Ai Za Zhi] 2005 Oct 20; Vol. 8 (5), pp. 440-3. - Publication Year :
- 2005
-
Abstract
- Background: The roles of nuclear factor kappa B (NF-kappa B) and activating protein 1 (AP-1) become well-known in cell apoptosis and proliferation and oncogenesis. This study aims to explore expression of NF-kappa B and AP-1 in non-small cell lung cancer (NSCLC), the relationship between them and their function on expression of cyclin D1 and caspase 3 in NSCLC.<br />Methods: Protein expression of NF-kappa B, AP-1 , cyclin D1 and caspase 3 was detected by Western blot and mRNA expression of cyclin D1 and caspase 3 by RT-PCR. Correlation between NF-kappa B and AP-1 was analyzed using bivariate correlate analysis.<br />Results: Of all 45 NSCLC patients, the expression of NF-kappa B and AP-1 in NSCLC was higher than that in normal lung tissues (0.6047 versus 0.2798, P < 0.01). Protein and mRNA expression of cyclin D1 in lung cancer tissues with higher NF-kappa B and AP-1 protein expression was higher than in those with lower NF-kappa B and AP-1 protein expression (P < 0.01), while protein and mRNA expression of caspase 3 in lung cancer tissues with higher NF-kappa B and AP-1 protein expression was lower than in those with lower NF-kappa B and AP-1 protein expression (P < 0.01). There was significant correlation between NF-kappa B and AP-1 (r=0.800, P < 0.01).<br />Conclusions: Transcription factors, NF-kappa B and AP-1 may play important roles in oncogenesis and development of NSCLC.
Details
- Language :
- Chinese
- ISSN :
- 1009-3419
- Volume :
- 8
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Zhongguo fei ai za zhi = Chinese journal of lung cancer
- Publication Type :
- Academic Journal
- Accession number :
- 21205529
- Full Text :
- https://doi.org/10.3779/j.issn.1009-3419.2005.05.18