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Comet-tail-like inflammatory infiltrate to polymer filaments develops in tension-free conditions.
- Source :
-
European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes [Eur Surg Res] 2011; Vol. 46 (2), pp. 73-81. Date of Electronic Publication: 2010 Dec 29. - Publication Year :
- 2011
-
Abstract
- Background: Mesh reinforcement in hiatal hernia repair becomes more frequent but is charged by complications such as erosion or stenosis of the oesophagus. These complications are accompanied by an intense inflammatory infiltrate around the polymer fibres. To characterize this effect, the response to polypropylene fibres in the absence of tension was examined.<br />Methods: In rats, polypropylene sutures (USP size 1, 3-0 and 7-0) were placed in the subcutis of the abdominal wall without knot or tension. On postoperative days 3, 7 and 21, specimens were excised. The expressions of c-myc, β-catenin, Notch3, COX-2, CD68 and Ki-67 were measured by immunohistochemistry.<br />Results: In the absence of tension, sutures were surrounded by a foreign body granuloma with an inflammatory infiltrate not encircling the fibre but forming almost symmetric comet-tail-like infiltrates on opposite sides. The expression of c-myc, β-catenin, Notch3, COX-2, CD68 and Ki-67 was significantly reduced over time in the comet tail, but not in the granuloma.<br />Conclusions: Even in tension-free conditions, surgical sutures cause a foreign body response with infiltrates of inflammatory cells. This reaction is shaped like a comet tail, and its extension depends on the diameter of the used fibre. Therefore, for reduction of perifilamental infiltrates, not only absence of tension is required, but also a small-sized fibre textile.<br /> (Copyright © 2010 S. Karger AG, Basel.)
- Subjects :
- Animals
Antigens, CD metabolism
Antigens, Differentiation, Myelomonocytic metabolism
Biocompatible Materials adverse effects
Biomechanical Phenomena
Cell Proliferation
Collagen metabolism
Cyclooxygenase 2 metabolism
Disease Models, Animal
Esophageal Stenosis etiology
Fibrosis
Foreign-Body Reaction metabolism
Gastroesophageal Reflux surgery
Hernia, Hiatal surgery
Humans
Ki-67 Antigen metabolism
Male
Materials Testing
Polymers adverse effects
Postoperative Complications metabolism
Rats
Rats, Sprague-Dawley
Surgical Mesh adverse effects
beta Catenin metabolism
Foreign-Body Reaction etiology
Foreign-Body Reaction pathology
Postoperative Complications etiology
Postoperative Complications pathology
Sutures adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1421-9921
- Volume :
- 46
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes
- Publication Type :
- Academic Journal
- Accession number :
- 21196740
- Full Text :
- https://doi.org/10.1159/000322250