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Lymphangiogenesis and cancer metastasis.
- Source :
-
Frontiers in bioscience (Landmark edition) [Front Biosci (Landmark Ed)] 2011 Jan 01; Vol. 16 (2), pp. 723-39. Date of Electronic Publication: 2011 Jan 01. - Publication Year :
- 2011
-
Abstract
- Lymphangiogenesis remains a fascinating biological process that plays a crucial role in both normal tissue development and several lymphatic diseases. The last few years have witnessed a rapid progression in understanding the development and regulation of the lymphatic system which provided insight on several pathological processes including cancer lymphatic metastasis. Lymphatic vasculature serves as a major route for tumour metastasis. The dissemination of malignant cells to the regional lymph nodes is an early step in the progression of many solid tumours and is an important determinant of staging and prognosis. Lymphangiogenesis is thought to play a pivotal role for cancer cells to metastasis to the regional lymph nodes. Several human solid tumours are now considered to be lymphangiogenic i.e. they have the ability to induce their own lymphatic vessels to establish metastasis. Hence, targeting lymphangiogenesis by developing anti-lymphangiogenic agents might constitute a novel way to prevent lymphatic progression in some tumours. Here, we have reviewed the development of the lymphatic system, the regulation of lymphangiogenesis and explored its relation to several human cancers.
- Subjects :
- 5'-Nucleotidase metabolism
Animals
Biomarkers metabolism
Homeodomain Proteins metabolism
Humans
Lymphatic Metastasis pathology
Membrane Glycoproteins metabolism
Neoplasms drug therapy
Neoplasms pathology
Neoplasms physiopathology
Receptors, Vascular Endothelial Growth Factor physiology
Signal Transduction physiology
Tumor Suppressor Proteins metabolism
Vascular Endothelial Growth Factor Receptor-3 metabolism
Vesicular Transport Proteins metabolism
Weibel-Palade Bodies metabolism
Lymphangiogenesis physiology
Lymphatic System physiopathology
Vascular Endothelial Growth Factors physiology
Subjects
Details
- Language :
- English
- ISSN :
- 2768-6698
- Volume :
- 16
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Frontiers in bioscience (Landmark edition)
- Publication Type :
- Academic Journal
- Accession number :
- 21196198
- Full Text :
- https://doi.org/10.2741/3715