Expression and prognostic relevance of the death receptor CD95 (Fas/APO1) in renal cell carcinomas.

Authors :: Macher-Goeppinger S
Bermejo JL
Wagener N
Hohenfellner M
Haferkamp A
Schirmacher P
Roth W
Source :: Cancer letters [Cancer Lett] 2011 Feb 28; Vol. 301 (2), pp. 203-11. Date of Electronic Publication: 2010 Dec 31.
Publication Year :: 2011
Abstract: CD95 (Fas/APO1) is one of the best known members of the death receptor family which can either mediate apoptosis or activate tumor-promoting pathways. Using a tissue microarray we investigated the association between the expression of CD95 and prognosis in 617 patients with renal cell carcinomas (RCCs). CD95 was expressed in the vast majority of RCCs. High CD95 expression was associated with lymph node metastasis and correlated negatively with disease-specific survival. Multivariate Cox regression analysis confirmed CD95 expression as an independent prognostic factor. In conclusion, high CD95 expression is a negative independent prognostic factor in RCCs which could be used to identify high-risk patients with a poor clinical prognosis.<br /> (Copyright Â© 2010 Elsevier Ireland Ltd. All rights reserved.)

Subjects :: Aged
Carcinoma, Renal Cell pathology
Fas Ligand Protein biosynthesis
Female
Humans
Immunohistochemistry statistics & numerical data
Kaplan-Meier Estimate
Kidney Neoplasms pathology
Male
Middle Aged
Neoplasm Staging
Prognosis
Proportional Hazards Models
Tissue Array Analysis
Biomarkers, Tumor biosynthesis
Carcinoma, Renal Cell metabolism
Kidney Neoplasms metabolism
fas Receptor biosynthesis

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