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Aortic and hepatic enhancement at multidetector CT: evaluation of optimal iodine dose determined by lean body weight.
- Source :
-
European journal of radiology [Eur J Radiol] 2011 Dec; Vol. 80 (3), pp. e273-7. Date of Electronic Publication: 2010 Dec 31. - Publication Year :
- 2011
-
Abstract
- Purpose: To determine the optimal iodine dose for aortic and hepatic enhancement at MDCT by comparing lean body weight (LBW) with total body weight (TBW).<br />Materials and Methods: This study was approved by our institutional review committee. One hundred and thirty-six patients were randomized into four groups: 550, 650, 750 mg iodine/(kg of LBW) and 600 mgI/(kg of TBW). The aortic and hepatic contrast enhancements (Δ HUs) during the portal venous-phase and variances of ΔHUs were compared.<br />Results: Mean ΔHUs for 550, 650, 750 mgI/kg LBW and 600 mgI/kg TBW were: 95.1, 109.9, 122.4, and 131.2HU, respectively, for the aorta. For the liver, 43.1, 55.4, 60.8, and 63.5 HU. Mean Δ HUs increased with iodine dose per kg LBW (p<0.01), but no significant difference between 750 mgI/kg LBW and 600 mgI/kg TBW groups. Hepatic enhancement increased by ≥50 HU in 94% of patients with 750 mg/kg LBW. Variance of hepatic enhancement was marginally greater in the 600 mgI/kg TBW than in the 550 and 750 mgI/kg LBW.<br />Conclusion: Hepatic enhancement variation was reduced with iodine doses based on LBW. Iodine dose of 750 mg iodine/kg LBW was appropriate to achieve hepatic enhancement≥50 HU in 94% of patients.<br /> (Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Body Weight
Dose-Response Relationship, Drug
Female
Humans
Male
Middle Aged
Radiographic Image Enhancement methods
Reproducibility of Results
Sensitivity and Specificity
Thinness diagnostic imaging
Algorithms
Aortography methods
Contrast Media administration & dosage
Iodine administration & dosage
Liver diagnostic imaging
Tomography, X-Ray Computed methods
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7727
- Volume :
- 80
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- European journal of radiology
- Publication Type :
- Academic Journal
- Accession number :
- 21195572
- Full Text :
- https://doi.org/10.1016/j.ejrad.2010.12.009