Back to Search
Start Over
Childhood craniopharyngioma in Macedonia: incidence and outcome after subtotal resection and cranial irradiation.
- Source :
-
World journal of pediatrics : WJP [World J Pediatr] 2011 Feb; Vol. 7 (1), pp. 74-8. Date of Electronic Publication: 2010 Dec 30. - Publication Year :
- 2011
-
Abstract
- Background: craniopharyngioma is a frequent tumor in children with challenging surgical, endocrine, and visual consequences. We evaluated our experience in treating craniopharyngioma and its incidence in Macedonia.<br />Methods: Thirteen children (9 male and 4 female) with craniopharyngioma (age 9.55 ± 3.74 years; range 2.90-15.11) who had been treated between 1989 and 2008 in Macedonia were reviewed.<br />Results: initial signs were vision disturbances (10 children), seizures (1), growth retardation (13), and diabetes insipidus (DI) (2). All children were subjected to subtotal surgical removal. Cranial irradiation was performed in 12 of the 13 children, and intracystic bleomycin was given to one child. The patients were followed up for 6-229 months (mean ± SD: 107.00 ± 74.04 months). All children had multiple pituitary deficiencies after surgical removal of the tumor. Body mass index increased from 16.93 ± 6.34 standard deviation scores (SDS) at diagnosis to 26.33 ± 5.91 SDS (P>0.005) at the last follow-up. DI was permanent in 9 of the 13 children, and multiple pituitary deficiencies were seen in all children. Treatment with growth hormone resulted in normalization of adult height from -1.27 ± 1.52 SDS at the start of the treatment to -0.13 ± 1.39 SDS at the last followup. The final height was not significantly lower than the genetic target height (P>0.005). The permanent deficit was visual impairment: blindness in one or both eyes in 4 children, bitemporal hemianopsia in 4, and other defects in 2. Recurrence of the disease was ruled out in one child after 31 months. No mortality was observed in the observation period of 104.92 ± 76.11 months.<br />Conclusions: the overall incidence of craniopharyngioma in the period of 1989-2008 in Macedonia was 1.43 per 1 000 000 person-years. Subtotal resection and systematic irradiation showed good life quality of survivors.
- Subjects :
- Adolescent
Antibiotics, Antineoplastic administration & dosage
Bleomycin administration & dosage
Child
Child, Preschool
Craniopharyngioma complications
Craniopharyngioma epidemiology
Craniopharyngioma radiotherapy
Craniopharyngioma surgery
Diabetes Insipidus drug therapy
Diabetes Insipidus etiology
Drug Therapy, Combination
Female
Follow-Up Studies
Growth Disorders drug therapy
Growth Disorders etiology
Human Growth Hormone therapeutic use
Humans
Incidence
Injections, Intralesional
Male
Pituitary Neoplasms complications
Pituitary Neoplasms epidemiology
Pituitary Neoplasms radiotherapy
Pituitary Neoplasms surgery
Quality of Life
Radiotherapy, Adjuvant methods
Republic of North Macedonia epidemiology
Retrospective Studies
Seizures etiology
Treatment Outcome
Vision Disorders etiology
Craniopharyngioma therapy
Pituitary Neoplasms therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1867-0687
- Volume :
- 7
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- World journal of pediatrics : WJP
- Publication Type :
- Academic Journal
- Accession number :
- 21191780
- Full Text :
- https://doi.org/10.1007/s12519-011-0250-3