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The study of aqueous extract of Pterocarpus marsupium Roxb. on cytokine TNF-α in type 2 diabetic rats.

Authors :
Halagappa K
Girish HN
Srinivasan BP
Source :
Indian journal of pharmacology [Indian J Pharmacol] 2010 Dec; Vol. 42 (6), pp. 392-6.
Publication Year :
2010

Abstract

Objective: This study was designed to investigate the effect of aqueous extract of Pterocarpus marsupium Roxb. on elevated inflammatory cytokine, tumor necrosis factor (TNF)-α in type 2 diabetic rats.<br />Materials and Methods: Type 2 diabetes was induced by administering streptozotocin (90 mg/kg, i.p.) in a neonatal rat model. Aqueous extract of P. marsupium at a dose of 100 and 200 mg/kg was given orally to desired group of animals for a period of 4 weeks. After 4 weeks of drug treatment, parameters such as fasting blood glucose, postprandial blood glucose, and TNF-α in serum were analyzed.<br />Results: Aqueous extract of P. marsupium at both doses, i.e., 100 and 200 mg/kg, decreased the fasting and postprandial blood glucose in type 2 diabetic rats. The 200 mg/kg had more pronounced effect on postprandial hyperglycemia. The drug also improved the body weight of diabetic animals. Cytokine TNF-α was found to be elevated in untreated diabetic rats due to chronic systemic inflammation. The aqueous extract at both doses significantly (P < 0.001) decreased the elevated TNF-α level in type 2 diabetic rats.<br />Conclusion: Modulation of cytokine TNF-α by the rasayana drug P. marsupium is related with its potential anti-diabetic activity.

Details

Language :
English
ISSN :
1998-3751
Volume :
42
Issue :
6
Database :
MEDLINE
Journal :
Indian journal of pharmacology
Publication Type :
Academic Journal
Accession number :
21189913
Full Text :
https://doi.org/10.4103/0253-7613.71922