Formulation and pharmacokinetic evaluation of hard gelatin capsule encapsulating lyophilized Vasa Swaras for improved stability and oral bioavailability of vasicine.

Authors :: Vyas T
Dash RP
Anandjiwala S
Nivsarkar M
Source :: Fitoterapia [Fitoterapia] 2011 Apr; Vol. 82 (3), pp. 446-53. Date of Electronic Publication: 2010 Dec 24.
Publication Year :: 2011
Abstract: The oral bioavailability of vasicine (1) was investigated in hard gelatin capsules of lyophilized Vasa Swaras (aqueous extract of Adhatoda vasica Nees.,Fam.: Acanthaceae) The rat pharmacokinetic profile of lyophilized Vasa Swaras, Vasa Swaras, vasicine (1) (chief marker compounds of A. vasica) and a marketed capsule formulation of A. vasica were compared. Vasicine (1) was found to be more orally bioavailable from lyophilized Vasa Swaras, with an overall minor conversion to vasicinone (2).<br /> (Copyright © 2010 Elsevier B.V. All rights reserved.)

Subjects :: Alkaloids metabolism
Animals
Biological Availability
Chemistry, Pharmaceutical methods
Drug Stability
Freeze Drying
Gelatin
Male
Plant Extracts metabolism
Quinazolines metabolism
Rats
Rats, Sprague-Dawley
Alkaloids pharmacokinetics
Capsules
Justicia chemistry
Plant Extracts pharmacokinetics
Quinazolines pharmacokinetics

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