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Low aryl hydrocarbon receptor-interacting protein expression is a better marker of invasiveness in somatotropinomas than Ki-67 and p53.
- Source :
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Neuroendocrinology [Neuroendocrinology] 2011; Vol. 94 (1), pp. 39-48. Date of Electronic Publication: 2010 Dec 18. - Publication Year :
- 2011
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Abstract
- Background: Some pituitary adenomas exhibit fast growth and invade surrounding structures. To date, there is no robust marker to predict invasiveness.<br />Aim: To evaluate Ki-67, p53 and aryl hydrocarbon receptor-interacting protein (AIP) expression and compare these between invasive and noninvasive somatotropinomas and nonfunctioning pituitary adenomas (NFPAs).<br />Methods: Protein expression was determined by immunohistochemistry. Tumors were classified according to percentage of immunolabeled nuclei for Ki-67 and p53. AIP immunopositivity was graded according to a score encompassing pattern and intensity. Invasiveness was defined according to radiological and surgical criteria.<br />Results: Thirty-eight sporadic somatotropinomas were studied. Median Ki-67 labeling index in invasive and noninvasive tumors was 1.6 (range 0-20.6) and 0.26 (0-2.2), respectively (p = 0.01). With a 2.3% cut-off point obtained by ROC curve analysis, invasive adenomas were distinguished with 100% specificity, 39% sensitivity, and 63% accuracy. Low AIP expression was also correlated with tumor invasiveness (p = 0.001), with sensitivity, specificity and accuracy of 78, 80, and 79%, respectively. Expression of p53 was not different among tumors. Twenty-nine NFPAs were studied, with no significant difference between Ki-67, p53 and AIP expression in invasive and noninvasive tumors. High AIP expression was more frequent in NFPAs, with Ki-67 >3% (p = 0.051), especially when only gonadotrope cell adenomas (n = 25) were considered (p = 0.012).<br />Conclusions: These data suggest, for the first time, that AIP is a better marker of invasiveness in somatotropinomas than Ki-67 and p53. In addition, low AIP expression is observed in invasive somatotropinomas, in contrast with high AIP expression in NFPAs (mainly gonadotrope cell tumors) with high proliferative indices.<br /> (Copyright © 2010 S. Karger AG, Basel.)
- Subjects :
- Adenoma diagnosis
Adenoma pathology
Adult
Aged
Aged, 80 and over
Cell Proliferation
Female
Growth Hormone metabolism
Humans
Male
Middle Aged
Neoplasm Invasiveness
Pituitary Neoplasms diagnosis
Pituitary Neoplasms pathology
Predictive Value of Tests
ROC Curve
Retrospective Studies
Sensitivity and Specificity
Adenoma metabolism
Biomarkers, Tumor metabolism
Intracellular Signaling Peptides and Proteins metabolism
Ki-67 Antigen metabolism
Pituitary Neoplasms metabolism
Tumor Suppressor Protein p53 metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1423-0194
- Volume :
- 94
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Neuroendocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 21178332
- Full Text :
- https://doi.org/10.1159/000322787