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IGF-I gene variability is associated with an increased risk for AD.
- Source :
-
Neurobiology of aging [Neurobiol Aging] 2011 Mar; Vol. 32 (3), pp. 556.e3-11. Date of Electronic Publication: 2010 Dec 22. - Publication Year :
- 2011
-
Abstract
- Insulin-like growth factor I (IGF-I), a neuroprotective factor with a wide spectrum of actions in the adult brain, is involved in the pathogenesis of Alzheimer's disease (AD). Circulating levels of IGF-I change in AD patients and are implicated in the clearance of brain amyloid beta (Aβ) complexes. To investigate this hypothesis, we screened the IGF-I gene for various well known single nucleotide polymorphisms (SNPs) covering % of the gene variability in a population of 2352 individuals. Genetic analysis indicated different distribution of genotypes of 1 single nucleotide polymorphism, and 1 extended haplotype in the AD population compared with healthy control subjects. In particular, the frequency of rs972936 GG genotype was significantly greater in AD patients than in control subjects (63% vs. 55%). The rs972936 GG genotype was associated with an increased risk for disease, independently of apolipoprotein E genotype, and with enhanced circulating levels of IGF-I. These findings suggest that polymorphisms within the IGF-I gene could infer greater risk for AD through their effect on IGF-I levels, and confirm the physiological role IGF-I in the pathogenesis of AD.<br /> (Copyright © 2011 IBRO. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Aged
Aged, 80 and over
Alzheimer Disease blood
Apolipoproteins E genetics
DNA Mutational Analysis methods
Female
Gelsolin genetics
Gene Frequency
Genotype
Humans
Insulin-Like Growth Factor I metabolism
Male
Prealbumin genetics
Risk Factors
Spain epidemiology
Statistics, Nonparametric
Alzheimer Disease epidemiology
Alzheimer Disease genetics
Insulin-Like Growth Factor I genetics
Polymorphism, Single Nucleotide genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1558-1497
- Volume :
- 32
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Neurobiology of aging
- Publication Type :
- Academic Journal
- Accession number :
- 21176999
- Full Text :
- https://doi.org/10.1016/j.neurobiolaging.2010.10.017