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Hypertension and angiogenesis in the aging kidney: a review.
- Source :
-
Archives of gerontology and geriatrics [Arch Gerontol Geriatr] 2011 May-Jun; Vol. 52 (3), pp. e93-102. Date of Electronic Publication: 2010 Dec 21. - Publication Year :
- 2011
-
Abstract
- With advanced aging, main components of the kidney are altered, including blood vessels, glomeruli and tubulointerstitium. Disruption in these 3 elements is interconnected and associated with several modifications, such as loss of kidney mass and systemic, metabolic and immunologic diseases. In this review we focus on renal blood vessels, the key role of hypertension and angiogenesis in the elderly kidney, the hemodynamic and molecular mechanisms underlying this aging process and the main factors involved. So far, the present data suggests a strong association between renal disease and hypertension and the impairment of regulatory mechanisms, such as angiogenesis in the aging kidney. The endothelium is a key player in vascular control and appears to be also disrupted in many compensatory functions (i.e., vasodilation). Perspectives for the management of the dysfunctional aging kidney are also addressed.<br /> (Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.)
- Subjects :
- Animals
Arginine analogs & derivatives
Arginine physiology
Female
Humans
Male
Mice
Nitric Oxide physiology
Rats
Renin-Angiotensin System physiology
Vascular Endothelial Growth Factors physiology
Aging physiology
Hypertension, Renal physiopathology
Kidney blood supply
Neovascularization, Physiologic
Subjects
Details
- Language :
- English
- ISSN :
- 1872-6976
- Volume :
- 52
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Archives of gerontology and geriatrics
- Publication Type :
- Academic Journal
- Accession number :
- 21176977
- Full Text :
- https://doi.org/10.1016/j.archger.2010.11.032