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Adriamycin nephropathy: a model of focal segmental glomerulosclerosis.
- Source :
-
Nephrology (Carlton, Vic.) [Nephrology (Carlton)] 2011 Jan; Vol. 16 (1), pp. 30-8. - Publication Year :
- 2011
-
Abstract
- Adriamycin nephropathy (AN) is a rodent model of chronic kidney disease that has been studied extensively and has enabled a greater understanding of the processes underlying the progression of chronic proteinuric renal disease. AN is characterized by podocyte injury followed by glomerulosclerosis, tubulointerstitial inflammation and fibrosis. Genetic studies have demonstrated a number of loci that alter both risk and severity of renal injury induced by Adriamycin. Adriamycin-induced renal injury has been shown in numerous studies to be modulated by both non-immune and immune factors, and has facilitated further study of mechanisms of tubulointerstitial injury. This review will outline the pharmacological behaviour of Adriamycin, and describe in detail the model of AN, including its key structural characteristics, genetic susceptibility and pathogenesis.<br /> (© 2011 The Authors. Nephrology © 2011 Asian Pacific Society of Nephrology.)
- Subjects :
- Animals
Genetic Predisposition to Disease
Glomerulosclerosis, Focal Segmental genetics
Glomerulosclerosis, Focal Segmental pathology
Kidney Glomerulus drug effects
Kidney Glomerulus pathology
Kidney Tubules drug effects
Kidney Tubules pathology
Mice
Rats
Disease Models, Animal
Doxorubicin pharmacology
Glomerulosclerosis, Focal Segmental chemically induced
Subjects
Details
- Language :
- English
- ISSN :
- 1440-1797
- Volume :
- 16
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nephrology (Carlton, Vic.)
- Publication Type :
- Academic Journal
- Accession number :
- 21175974
- Full Text :
- https://doi.org/10.1111/j.1440-1797.2010.01383.x