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Synthesis and stereochemical assignment of (+)-chamuvarinin.
- Source :
-
Organic letters [Org Lett] 2011 Feb 04; Vol. 13 (3), pp. 514-7. Date of Electronic Publication: 2010 Dec 21. - Publication Year :
- 2011
-
Abstract
- A stereocontrolled total synthesis of (+)-chamuvarinin, isolated from the root extract of Uvaria Chamae, utilizes a convergent modular strategy to construct the adjacently linked C15-C28 ether array, followed by a late-stage Julia-Kocienski olefination to append the butenolide motif. This constitutes the first total synthesis of (+)-chamuvarinin, defining the relative and absolute configuration of this unique annonaceous acetogenin.
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 13
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 21174397
- Full Text :
- https://doi.org/10.1021/ol1028699