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Flavonoids inhibit angiogenic cytokine production by human glioma cells.
- Source :
-
Phytotherapy research : PTR [Phytother Res] 2011 Jun; Vol. 25 (6), pp. 916-21. Date of Electronic Publication: 2010 Dec 17. - Publication Year :
- 2011
-
Abstract
- VEGF and TGF-β1 are cytokines that stimulate tissue invasion and angiogenesis. These factors are considered as molecular targets for the therapy of glioblastoma. Bevacizumab, a recombinant humanized monoclonal antibody developed against VEGF, inhibits endothelial cell proliferation and vessel formation. Flavonoids obtained from Dimorphandra mollis and Croton betulaster have been described as proliferation inhibitors of a human glioblastoma derived cell line. VEGF and TGF-β1 levels were dosed by ELISA in a GL-15 cell line treated with bevacizumab and also with the flavonoids rutin, 5-hydroxy-7,4'-dimethoxyflavone, casticin, apigenin and penduletin. Rutin reduced the VEGF and TGF-β1 levels after 24 h but not after 72 h. The other flavonoids significantly reduced TGF-β1 production. Bevacizumab reduced only the VEGF levels in the supernatant from GL-15 cultures. These results suggest that the flavonoids studied, and commonly used in popular medicine, present an interesting subject of study due to their potential effect as angiogenic factor inhibitors.<br /> (Copyright © 2010 John Wiley & Sons, Ltd.)
- Subjects :
- Antibodies, Monoclonal pharmacology
Antibodies, Monoclonal, Humanized
Bevacizumab
Croton chemistry
Fabaceae chemistry
Glioblastoma blood supply
Humans
Neovascularization, Pathologic metabolism
Phytotherapy
Angiogenesis Inhibitors pharmacology
Cytokines antagonists & inhibitors
Cytokines biosynthesis
Flavonoids pharmacology
Glioblastoma drug therapy
Glioblastoma metabolism
Plant Extracts pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1099-1573
- Volume :
- 25
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Phytotherapy research : PTR
- Publication Type :
- Academic Journal
- Accession number :
- 21170924
- Full Text :
- https://doi.org/10.1002/ptr.3338