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Association of genetic variations in the STAT4 and IRF7/KIAA1542 regions with systemic lupus erythematosus in a Northern Han Chinese population.
- Source :
-
Human immunology [Hum Immunol] 2011 Mar; Vol. 72 (3), pp. 249-55. Date of Electronic Publication: 2010 Dec 15. - Publication Year :
- 2011
-
Abstract
- Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease with complex genetic inheritance. Genome-wide association studies have identified SLE susceptibility variations at the IRF7/KIAA1542 locus and with STAT4 gene in European populations. We decided to investigate the association of single-nucleotide polymorphisms (SNPs) in the IRF7/KIAA1542 region (rs4963128, rs2246614, and rs702966) and in STAT4 (rs7574865 and rs7582694) with SLE disease in a Northern Han Chinese population of 748 patients and 750 healthy controls. Our study indicated a strong association between rs7574865 (odds ratio = 0.68; 95% confidence interval 0.59-0.79; p = 1.57 × 10(-6)) and SLE and between rs7574865 and the production of anti-Sm antibodies. Additionally, rs4963128 and rs2246614 were correlated with a variety of clinical subphenotypes, such as lupus nephritis, arthritis, and the production of anti-SSA/B autoantibodies, despite a lack of significant association between these two SNPs and SLE disease susceptibility in general.<br /> (Copyright © 2011 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Arthritis genetics
Autoantibodies
China
Female
Genetic Variation
Genome-Wide Association Study
Genotype
Humans
Lupus Nephritis genetics
Male
Middle Aged
Signal Transduction
Genetic Predisposition to Disease
Interferon Regulatory Factor-7 genetics
Lupus Erythematosus, Systemic genetics
Polymorphism, Single Nucleotide
STAT4 Transcription Factor genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1166
- Volume :
- 72
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Human immunology
- Publication Type :
- Academic Journal
- Accession number :
- 21167895
- Full Text :
- https://doi.org/10.1016/j.humimm.2010.12.011