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Assessment of left ventricular volumes, ejection fraction and mass. Comparison of model-based analysis of ECG-gated (⁹⁹m)Tc-SPECT and ¹⁸F-FDG-PET.
- Source :
-
Nuklearmedizin. Nuclear medicine [Nuklearmedizin] 2011; Vol. 50 (1), pp. 9-14. Date of Electronic Publication: 2010 Dec 17. - Publication Year :
- 2011
-
Abstract
- Aim: We compared and delineated possible differences of model-based analysis of ECG-gated SPECT using (⁹⁹m)Tc-sestamibi (Tc-SPECT) with ECG-gated ¹⁸F-fluorodeoxyglucose-PET (FDG-PET) for determination of end-diastolic (EDV) and end-systolic (ESV) cardiac volumes, left ventricular ejection fraction (LVEF), and myocardial mass (LVMM).<br />Patients, Methods: 24 patients (21 men; age: 54±12years) with coronary artery disease underwent Tc-SPECT and FDG-PET imaging for evaluation of myocardial perfusion and viability. By using model-based analysis EDV, ESV, LVEF and LVMM were calculated from short axis images of both Tc-SPECT and FDG-PET.<br />Results: Left ventricular volumes by Tc-SPECT and FDG-PET were 176±60 ml and 181±59 ml for EDV, and 97±44 ml and 103±45 ml for ESV respectively, LVEF was 47±8% by Tc-SPECT and 45±9% by FDG-PET. The LVMM was 214±40 g (Tc-SPECT) and 202±43 g (FDG-PET) (all p = NS, paired t-test). A significant correlation was observed between Tc-SPECT and FDG-PET imaging for calculation of EDV (r = 0.93), ESV (r = 0.93), LVEF (r = 0.83) and LVMM (r = 0.72).<br />Conclusion: ECG-gated Tc-SPECT and FDG-PET using two tracers with different characteristics (perfusion versus metabolism) showed close agreement concerning measurements of left ventricular volumes, contractile function and myocardial mass by using a model-based analysis.
- Subjects :
- Female
Humans
Male
Middle Aged
Organ Size
Positron-Emission Tomography methods
Radiopharmaceuticals pharmacokinetics
Reproducibility of Results
Sensitivity and Specificity
Tomography, Emission-Computed, Single-Photon methods
Ventricular Dysfunction, Left metabolism
Cardiac-Gated Imaging Techniques methods
Fluorodeoxyglucose F18 pharmacokinetics
Stroke Volume
Technetium pharmacokinetics
Ventricular Dysfunction, Left diagnostic imaging
Subjects
Details
- Language :
- English
- ISSN :
- 0029-5566
- Volume :
- 50
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nuklearmedizin. Nuclear medicine
- Publication Type :
- Academic Journal
- Accession number :
- 21165540
- Full Text :
- https://doi.org/10.3413/nukmed-0350-10-09