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Progress in filovirus vaccine development: evaluating the potential for clinical use.
- Source :
-
Expert review of vaccines [Expert Rev Vaccines] 2011 Jan; Vol. 10 (1), pp. 63-77. - Publication Year :
- 2011
-
Abstract
- Marburg and Ebola viruses cause severe hemorrhagic fever in humans and nonhuman primates. Currently, there are no effective treatments and no licensed vaccines; although a number of vaccine platforms have proven successful in animal models. The ideal filovirus vaccine candidate should be able to provide rapid protection following a single immunization, have the potential to work postexposure and be cross-reactive or multivalent against all Marburg virus strains and all relevant Ebola virus species and strains. Currently, there are multiple platforms that have provided prophylactic protection in nonhuman primates, including DNA, recombinant adenovirus serotype 5, recombinant human parainfluenza virus 3 and virus-like particles. In addition, a single platform, recombinant vesicular stomatitis virus, has demonstrated both prophylactic and postexposure protection in nonhuman primates. These results demonstrate that achieving a vaccine that is protective against filoviruses is possible; the challenge now is to prove its safety and efficacy in order to obtain a vaccine that is ready for human use.
- Subjects :
- Adenoviridae genetics
Animals
Disease Models, Animal
Drug Carriers
Ebolavirus genetics
Genetic Vectors
Humans
Marburgvirus genetics
Parainfluenza Virus 3, Human genetics
Primates
Vaccines, DNA adverse effects
Vaccines, DNA genetics
Vaccines, DNA immunology
Vaccines, Synthetic adverse effects
Vaccines, Synthetic genetics
Vaccines, Synthetic immunology
Vesiculovirus genetics
Viral Vaccines adverse effects
Viral Vaccines genetics
Ebolavirus immunology
Hemorrhagic Fever, Ebola prevention & control
Marburg Virus Disease prevention & control
Marburgvirus immunology
Viral Vaccines immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1744-8395
- Volume :
- 10
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Expert review of vaccines
- Publication Type :
- Academic Journal
- Accession number :
- 21162622
- Full Text :
- https://doi.org/10.1586/erv.10.152