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The BK virus in renal transplant recipients-review of pathogenesis, diagnosis, and treatment.
- Source :
-
Pediatric nephrology (Berlin, Germany) [Pediatr Nephrol] 2011 Oct; Vol. 26 (10), pp. 1763-74. Date of Electronic Publication: 2010 Dec 15. - Publication Year :
- 2011
-
Abstract
- The BK virus, a DNA virus from the Polyomavirus group, represents an opportunistic infection of immunosuppressed transplant recipients. Though the virus was discovered approximately 40 years ago, the emergence of BK virus nephropathy since 1995 onwards, with associated high graft loss rates, has revolutionized renal transplantation medicine. Kidney transplant professionals realized that the consequences of over-immunosuppression were as severe as the consequences of under-immunosuppression and we entered the era of immunosuppressive minimization. Despite this recognition, the optimal testing type for BK virus infections and frequency of testing are hotly debated. Similarly, optimal treatment strategies remain sources of intense controversy. The authors review the current strategies of screening, diagnosis, and possible treatment, and also review the amount and quality of evidence in favor or against. Similarities and differences between cytomegalovirus, Epstein-Barr virus, and BV virus, the three major viral infections in kidney transplantation, are highlighted.
- Subjects :
- Antiviral Agents therapeutic use
Child
Cidofovir
Cytosine analogs & derivatives
Cytosine therapeutic use
Humans
Immunosuppressive Agents administration & dosage
Immunosuppressive Agents adverse effects
Isoxazoles therapeutic use
Leflunomide
Organophosphonates therapeutic use
Polyomavirus Infections diagnosis
Polyomavirus Infections pathology
Polyomavirus Infections virology
Reoperation
Treatment Failure
BK Virus
Kidney Transplantation physiology
Polyomavirus Infections therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1432-198X
- Volume :
- 26
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Pediatric nephrology (Berlin, Germany)
- Publication Type :
- Academic Journal
- Accession number :
- 21161285
- Full Text :
- https://doi.org/10.1007/s00467-010-1716-6