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Multifunctional polyglycerol-grafted Fe₃O₄@SiO₂ nanoparticles for targeting ovarian cancer cells.
- Source :
-
Biomaterials [Biomaterials] 2011 Mar; Vol. 32 (8), pp. 2166-73. Date of Electronic Publication: 2010 Dec 13. - Publication Year :
- 2011
-
Abstract
- Ligand-mediated magnetic resonance (MR) contrast agents would be highly desirable for cancer diagnosis. In the present study, nanoparticles of Fe₃O₄ core with fluorescent SiO₂ shell were synthesized and grafted with hyperbranched polyglycerol (HPG-grafted Fe₃O₄@SiO₂ nanoparticles). These nanoparticles have a hydrodynamic diameter of 47.0 ± 4.0 nm, and are very stable in aqueous solution as well as in cell culture medium. Numerous surface hydroxyl groups of these nanoparticles were conjugated with folic acid by a thiol 'click' reaction. The successful covalent attachment of folic acid on the nanoparticles was confirmed by FTIR and XPS analyses. Both MR imaging and fluorescence microscopy show significant preferential uptake of the folic acid-conjugated polyglycerol-grafted Fe₃O₄@SiO₂ (FA-HPG-grafted Fe₃O₄@SiO₂) nanoparticles by human ovarian carcinoma cells (SKOV-3) as compared to macrophages and fibroblasts. Such nanoparticles can potentially be used to provide real-time imaging in ovarian cancer resection.<br /> (Copyright © 2010 Elsevier Ltd. All rights reserved.)
- Subjects :
- Biocompatible Materials chemistry
Cell Line, Tumor
Female
Folic Acid chemistry
Humans
Magnetic Resonance Imaging methods
Magnetics
Materials Testing
Molecular Structure
Ovarian Neoplasms pathology
Spectroscopy, Fourier Transform Infrared
Diagnostic Imaging methods
Ferric Compounds chemistry
Glycerol chemistry
Metal Nanoparticles chemistry
Ovarian Neoplasms diagnosis
Polymers chemistry
Silicon Dioxide chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1878-5905
- Volume :
- 32
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Biomaterials
- Publication Type :
- Academic Journal
- Accession number :
- 21146869
- Full Text :
- https://doi.org/10.1016/j.biomaterials.2010.11.042