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Usefulness of lipoprotein ratios in assessing carotid atherosclerosis in Japanese type 2 diabetic patients.
- Source :
-
Atherosclerosis [Atherosclerosis] 2011 Feb; Vol. 214 (2), pp. 442-7. Date of Electronic Publication: 2010 Nov 03. - Publication Year :
- 2011
-
Abstract
- Objective: It is indicated that total/HDL cholesterol and LDL/HDL cholesterol ratios have more predictive power for cardiovascular disease compared to classic lipid parameters. However, there have been few reports about the usefulness of these indices for the assessment of early stage atherosclerosis in Japanese type 2 diabetic subjects.<br />Methods: We examined the relation between various lipid parameters and carotid atherosclerosis in 934 type 2 diabetic subjects without apparent atherosclerotic diseases (males, 71.7%; age, 59.6 ± 10.5 years (mean ± SD)). Serum concentrations of total cholesterol (TC), HDL cholesterol (HDL-C), and triglyceride were measured. LDL cholesterol (LDL-C) level was calculated using the Friedewald formula. The presence of carotid plaque and intima-media thickness (IMT) were evaluated by ultrasonography.<br />Results: A stepwise multivariate regression analysis demonstrated that HDL-C (β = -0.110, p<0.001), TC/HDL-C (β = 0.132, p < 0.001) and LDL-C/HDL-C ratios (β = 0.132, p < 0.001) were independent determinants of IMT even after adjustment of other conventional risk factors. However, there was no significant correlation between IMT and TC, triglyceride, LDL-C, and non-HDL-C levels. TC/HDL-C and LDL-C/HDL-C ratios and non-HDL-C levels were significantly higher, but HDL-C levels were significantly lower in patients with carotid plaque than those without it (p < 0.05). There was no significant difference between the groups regarding TC, LDL-C, and triglyceride levels. Furthermore, TC/HDL-C (OR; 1.34, p < 0.001) and LDL-C/HDL-C (OR; 1.54, p < 0.001) ratios showed a positive and linear relationship with the prevalence of carotid plaque, whether covariates were adjusted or not.<br />Conclusions: TC/HDL-C and LDL-C/HDL-C ratios are useful as a tool to assess the risk of early stage atherosclerosis in Japanese type 2 diabetic patients.<br /> (Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.)
- Subjects :
- Aged
Biomarkers blood
Carotid Artery Diseases blood
Carotid Artery Diseases diagnostic imaging
Carotid Artery Diseases ethnology
Carotid Artery Diseases etiology
Chi-Square Distribution
Cross-Sectional Studies
Diabetes Mellitus, Type 2 ethnology
Diabetic Angiopathies blood
Diabetic Angiopathies diagnostic imaging
Diabetic Angiopathies ethnology
Diabetic Angiopathies etiology
Female
Humans
Japan epidemiology
Logistic Models
Male
Middle Aged
Odds Ratio
Predictive Value of Tests
ROC Curve
Risk Assessment
Risk Factors
Ultrasonography
Asian People statistics & numerical data
Carotid Artery Diseases diagnosis
Cholesterol, HDL blood
Cholesterol, LDL blood
Diabetes Mellitus, Type 2 complications
Diabetic Angiopathies diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1484
- Volume :
- 214
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Atherosclerosis
- Publication Type :
- Academic Journal
- Accession number :
- 21146820
- Full Text :
- https://doi.org/10.1016/j.atherosclerosis.2010.10.035