[Molecular actors in Alzheimer's disease: which diagnostic and therapeutic consequences?].

Authors :: Buée L
Blum D
Bombois S
Buée-Scherrer V
Caillet-Boudin ML
Colin M
Deramecourt V
Dhaenens CM
Galas MC
Hamdane M
Humez S
Maurage CA
Pasquier F
Sablonnière B
Schraen-Maschke S
Sergeant N
Source :: Therapie [Therapie] 2010 Sep-Oct; Vol. 65 (5), pp. 401-7. Date of Electronic Publication: 2010 Dec 13.
Publication Year :: 2010
Abstract: Alzheimer's disease is a neurodegenerative disorder characterized by neuropathological lesions: amyloid deposits and neurofibrillary degeneration. However, the links between these two brain hallmarks are still poorly understood. Until now, mainly amyloid pathology has been targeted un many clinical trials without any success. Both new therapeutic strategies and diagnosis improvement are needed.

Subjects :: Alzheimer Disease diagnosis
Alzheimer Disease therapy
Amyloid beta-Protein Precursor metabolism
Animals
Humans
Alzheimer Disease physiopathology
Amyloid beta-Peptides metabolism
Neurofibrillary Tangles pathology

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