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Enantioselective synthesis of optically pure β-amino ketones and γ-aryl amines by Rh-catalyzed asymmetric hydrogenation.
- Source :
-
The Journal of organic chemistry [J Org Chem] 2011 Jan 07; Vol. 76 (1), pp. 332-4. Date of Electronic Publication: 2010 Dec 09. - Publication Year :
- 2011
-
Abstract
- A series of optically pure β-amino ketones have been synthesized in high enantioselectivities (ee > 99%) by Rh-DuanPhos-catalyzed asymmetric hydrogenation of readily prepared β-keto enamides. Further reduction of these β-amino ketones with hydrogen and Pd/C leads to the formation of a variety of protected enantiomerically pure γ-aryl amines (ee > 99%), which are key building blocks in many bioactive molecules.
Details
- Language :
- English
- ISSN :
- 1520-6904
- Volume :
- 76
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The Journal of organic chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 21141916
- Full Text :
- https://doi.org/10.1021/jo102091f