Back to Search
Start Over
Induction of a Th-1-biased IgG subclass response against equine herpesvirus type 1 in horses previously infected with type 4 virus.
- Source :
-
The Journal of veterinary medical science [J Vet Med Sci] 2011 Apr; Vol. 73 (4), pp. 535-9. Date of Electronic Publication: 2010 Dec 06. - Publication Year :
- 2011
-
Abstract
- An immunoglobulin G (IgG) subclass response against equine herpesvirus type 1 (EHV-1) infection was investigated in horses that were naïve to EHV-1/4 and those that had previously been exposed to EHV-4. The IgG subclass response was determined by an ELISA using EHV-1-specific recombinant gG protein as an antigen. In most horses naïve to EHV-1/4, IgGa, IgGb, and IgG(T) were induced after experimental infection with EHV-1. In contrast, a subclass response dominated by IgGa and IgGb, with no apparent increase in IgG(T), was observed after EHV-1 infection in horses previously infected with EHV-4. Horses naturally infected with EHV-1 in the field showed similar responses. These results indicated that pre-infection with EHV-4 induced a Th-1-biased IgG subclass response against subsequent EHV-1 infection.
- Subjects :
- Animals
Herpesviridae Infections blood
Herpesviridae Infections immunology
Horse Diseases immunology
Horses
Th1 Cells physiology
Antibodies, Viral blood
Herpesviridae Infections veterinary
Herpesvirus 1, Equid immunology
Herpesvirus 4, Equid immunology
Horse Diseases virology
Immunoglobulin G blood
Subjects
Details
- Language :
- English
- ISSN :
- 0916-7250
- Volume :
- 73
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The Journal of veterinary medical science
- Publication Type :
- Academic Journal
- Accession number :
- 21139350
- Full Text :
- https://doi.org/10.1292/jvms.10-0456