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Biomarkers of neurological status in HIV infection: a 3-year study.
- Source :
-
Proteomics. Clinical applications [Proteomics Clin Appl] 2010 Mar; Vol. 4 (3), pp. 295-303. Date of Electronic Publication: 2010 Jan 04. - Publication Year :
- 2010
-
Abstract
- Purpose: To evaluate circulating cytokines and chemokines as correlates of the degree of brain injury in individuals with advanced human immunodeficiency virus (HIV) infection.<br />Experimental Design: Study participants included ten well-characterized subjects in advanced stage HIV infection. High-throughput multiplexed analysis was used to quantify markers of interest at baseline and 3 years later in the clinical course. Objective measurements of the brain were derived in vivo with quantitative magnetic resonance segmentation algorithms and with diffusion tensor imaging.<br />Results: Of the markers examined, monocyte chemoattractant protein-1 (MCP-1 or CCL-2) was the most prominent correlate of brain injury. Elevated MCP-1 levels correlated with brain white matter alterations at the initial assessment. The relationship to injury was more extensive 3 years later; elevated MCP-1 was significantly correlated with measures of brain microstructural alterations and of abject atrophy.<br />Conclusions and Clinical Relevance: The findings build on our prior observations that elevated MCP-1 levels may be a useful predictive marker for HIV-associated neurocognitive disorder. As a potent chemoattractant, MCP-1 may mediate injury through participation in self-reinforcing cycles of chronic immune activation and cytokine/chemokine-mediated neurotoxicity.<br /> (Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Subjects :
- AIDS-Associated Nephropathy complications
Adult
Atrophy diagnosis
Atrophy metabolism
Biomarkers blood
Brain pathology
Brain Injuries complications
Brain Injuries diagnosis
Brain Injuries metabolism
Chemokines blood
Chemokines metabolism
Female
Follow-Up Studies
HIV Infections complications
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Middle Aged
AIDS-Associated Nephropathy metabolism
Biomarkers metabolism
Brain metabolism
HIV Infections metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1862-8354
- Volume :
- 4
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Proteomics. Clinical applications
- Publication Type :
- Academic Journal
- Accession number :
- 21137050
- Full Text :
- https://doi.org/10.1002/prca.200900083