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Subacute proteome changes following traumatic injury of the developing brain: Implications for a dysregulation of neuronal migration and neurite arborization.

Authors :
Kaindl AM
Zabel C
Stefovska V
Lehnert R
Sifringer M
Klose J
Ikonomidou C
Source :
Proteomics. Clinical applications [Proteomics Clin Appl] 2007 Jul; Vol. 1 (7), pp. 640-9. Date of Electronic Publication: 2007 Jun 06.
Publication Year :
2007

Abstract

Traumatic brain injury (TBI) is a major cause of morbidity and mortality among children and adolescents. To gain insight into developmental events influenced by TBI, we analyzed subacute mouse brain proteome changes in a percussion head trauma model at P7 ipsi- and contralateral to the site of injury. The comparison of brain proteomes of trauma mice and controls revealed reproducible changes in the intensity of 28 proteins (30 protein spots) in response to trauma. The changes detected suggest that TBI leads to apoptosis, inflammation, and oxidative stress. These changes were consistent with our results of histological and biochemical evaluation of the brains which revealed widespread apoptotic neurodegeneration, microglia activation, and increased levels of protein carbonyls. Furthermore, we detected changes in proteins involved in neuronal migration as well as axonal and dendritic growth and guidance, suggesting interference of trauma with these developmental events.<br /> (Copyright © 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Details

Language :
English
ISSN :
1862-8346
Volume :
1
Issue :
7
Database :
MEDLINE
Journal :
Proteomics. Clinical applications
Publication Type :
Academic Journal
Accession number :
21136719
Full Text :
https://doi.org/10.1002/prca.200600696