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Fetal risk assessment in pregnancies complicated by diabetes mellitus.
- Source :
-
Journal of diabetes science and technology [J Diabetes Sci Technol] 2010 Nov 01; Vol. 4 (6), pp. 1368-73. Date of Electronic Publication: 2010 Nov 01. - Publication Year :
- 2010
-
Abstract
- Background: Hypoglycemia and hyperglycemia can pose a number of serious risks to pregnant mothers with diabetes, but these risks are not always related to glucose concentrations directly. Previous studies have shown the utility of using mathematical transformation functions to create patient risk profiles that can then be used to analyze and predict adverse outcomes in individuals with diabetes. We propose a novel use of these functions to analyze the risks posed to the fetus in pregnancies complicated by diabetes.<br />Methods: We retrospectively analyzed 71 h continuous glucose monitoring system (CGMS Gold, Medtronic Northridge, CA) third trimester tracings obtained during a normal pregnancy and in those complicated by gestational diabetes mellitus (GDM), type 2 diabetes mellitus (T2DM), and type 1 diabetes mellitus (T1DM). We then used a transformation function to calculate fetal and maternal risk in each case.<br />Results: In the normal pregnancy (0.93), the risk was at a minimum. Along with mean glucose values, the risk increased in those cases where gestation was complicated by GDM (3.12), T2DM (7.85), and T1DM (16.94). In contrast, the original patient risk profile yielded a minimal value for the GDM tracings.<br />Conclusions: Total fetal risk increases from normal to GDM to T2DM to T1DM pregnancies. This new risk assignment better distinguishes the stages of fetal risk than the original method and therefore may be useful in future clinical trials and applications to predict risk for adverse outcomes in pregnancies complicated by diabetes.<br /> (© 2010 Diabetes Technology Society.)
- Subjects :
- Diabetes Complications blood
Diabetes Mellitus, Type 1 blood
Diabetes Mellitus, Type 2 blood
Female
Fetal Diseases blood
Humans
Monitoring, Physiologic
Pregnancy
Pregnancy Trimester, Third blood
Retrospective Studies
Risk Assessment
Risk Factors
Time Factors
Blood Glucose metabolism
Diabetes Complications etiology
Diabetes Mellitus, Type 1 complications
Diabetes Mellitus, Type 2 complications
Diabetes, Gestational blood
Fetal Diseases etiology
Pregnancy in Diabetics
Subjects
Details
- Language :
- English
- ISSN :
- 1932-2968
- Volume :
- 4
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of diabetes science and technology
- Publication Type :
- Academic Journal
- Accession number :
- 21129331
- Full Text :
- https://doi.org/10.1177/193229681000400610