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Probable cutaneous hypersensitivity to carboplatin single-agent chemotherapy in a dog.
- Source :
-
The Journal of small animal practice [J Small Anim Pract] 2010 Dec; Vol. 51 (12), pp. 654-6. - Publication Year :
- 2010
-
Abstract
- Carboplatin is usually a well-tolerated drug and has many applications in veterinary oncology. The side effects of carboplatin described in the veterinary literature include myelotoxicity, nephrotoxicity, digestive and appetite disorders. In 114 dogs treated by single-agent chemotherapy with carboplatin, we observed a rate of non-haematological toxicities of 19·3% (personal observation). This case report describes the first case of cutaneous delayed-hypersensitivity to carboplatin in a dog, diagnosed according to the official ABON-system, which determines a causal association between a suspected product and a reported reaction (A=probable, B=possible, O=unclassifiable and N=unlikely), and an experimental intradermal skin test. Antihistamines were used to treat the reaction, and future carboplatin treatments were adjusted by premedication with corticosteroids, prolonged infusion and a reduction of 20% of the first dose of carboplatin. No further reactions were noted during the following treatments.<br /> (© 2010 British Small Animal Veterinary Association.)
- Subjects :
- Animals
Antineoplastic Agents therapeutic use
Carboplatin therapeutic use
Dog Diseases drug therapy
Dogs
Male
Nose Neoplasms drug therapy
Nose Neoplasms veterinary
Antineoplastic Agents adverse effects
Carboplatin adverse effects
Dog Diseases chemically induced
Drug Hypersensitivity veterinary
Subjects
Details
- Language :
- English
- ISSN :
- 1748-5827
- Volume :
- 51
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- The Journal of small animal practice
- Publication Type :
- Academic Journal
- Accession number :
- 21121921
- Full Text :
- https://doi.org/10.1111/j.1748-5827.2010.01002.x