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Mupirocin-resistant Staphylococcus aureus after long-term treatment of patients with epidermolysis bullosa.
- Source :
-
Journal of the American Academy of Dermatology [J Am Acad Dermatol] 1990 May; Vol. 22 (5 Pt 1), pp. 893-5. - Publication Year :
- 1990
-
Abstract
- In a long-term, open study, 47 patients with epidermolysis bullosa were treated with topical 2% mupirocin (Bactroban) ointment to decrease bacterial infection and promote wound healing. This antibiotic is effective against gram-positive but not gram-negative organisms. No significant adverse effects were noted, although some patients have been treated for more than 4 years. We sought evidence in this patient population for the appearance of bacterial strains with decreased sensitivity to mupirocin. In five patients cultures from nonhealing wounds revealed Staphylococcus aureus resistance to mupirocin. Four of these patients were given oral antibiotics to which S. aureus was sensitive; they improved clinically, and cultures of their wounds became negative for pathogens.
- Subjects :
- Adult
Anti-Bacterial Agents administration & dosage
Child
Drug Resistance, Microbial
Epidermolysis Bullosa microbiology
Fatty Acids administration & dosage
Fatty Acids therapeutic use
Humans
Mupirocin
Ointments
Penicillin Resistance
Time Factors
Wound Healing drug effects
Anti-Bacterial Agents therapeutic use
Epidermolysis Bullosa drug therapy
Staphylococcal Skin Infections drug therapy
Staphylococcus aureus drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0190-9622
- Volume :
- 22
- Issue :
- 5 Pt 1
- Database :
- MEDLINE
- Journal :
- Journal of the American Academy of Dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 2112168
- Full Text :
- https://doi.org/10.1016/0190-9622(90)70120-7