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Drug hypersensitivity in students from São Paulo, Brazil.
- Source :
-
Clinics (Sao Paulo, Brazil) [Clinics (Sao Paulo)] 2010; Vol. 65 (10), pp. 1009-11. - Publication Year :
- 2010
-
Abstract
- Background: Drug hypersensitivity is responsible for substantial mortality and morbidity, and increased health costs. However, epidemiological data on drug hypersensitivity in general or specific populations are scarce.<br />Methods: We performed a cross-sectional survey of 1015 university students, using a self-reported questionnaire.<br />Results: The prevalence of self-reported drug hypersensitivity was 12,11% (123/1015). The most frequently implicated drugs were non-steroidal anti-inflammatory drugs (45,9%) and beta-lactam and sulfonamide antibiotics (25,40%). The majority of the patients reported dermatological manifestations (99), followed by respiratory (40), digestive (23) and other (19). Forty-five patients had an immediate type reaction, and 76,72% (89) had the drug by oral route.<br />Conclusion: The results showed that drug hypersensitivity is highly prevalent in university students, and that nonsteroidal anti-inflammatory drug and antibiotics (beta-lactams and sulfonamide) are the most frequently concerned drugs.
- Subjects :
- Adolescent
Adult
Anti-Inflammatory Agents, Non-Steroidal adverse effects
Brazil epidemiology
Cross-Sectional Studies
Drug Hypersensitivity classification
Female
Humans
Male
Middle Aged
Prevalence
Sulfonamides adverse effects
Young Adult
beta-Lactams adverse effects
Drug Hypersensitivity epidemiology
Students statistics & numerical data
Subjects
Details
- Language :
- English
- ISSN :
- 1980-5322
- Volume :
- 65
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Clinics (Sao Paulo, Brazil)
- Publication Type :
- Academic Journal
- Accession number :
- 21120302
- Full Text :
- https://doi.org/10.1590/s1807-59322010001000014