Back to Search
Start Over
Atypical Pasteurella strains producing a toxin similar to the dermonecrotic toxin of Pasteurella multocida subspecies multocida.
- Source :
-
The Veterinary record [Vet Rec] 1990 Apr 28; Vol. 126 (17), pp. 434-7. - Publication Year :
- 1990
-
Abstract
- This paper is the first report of the production of a dermonecrotic toxin by pasteurella strains that do not belong to the species Pasteurella multocida subspecies multocida. Four strains, isolated from cattle with atrophic rhinitis, were characterised phenotypically. The strains were related to pasteurellaceae, but their taxonomic position remained unclear. The strains produced a toxin that caused a haemorrhagic dermonecrosis in guinea pigs and was lethal to mice. Both effects were neutralised by an antiserum against the purified dermonecrotic toxin of P multocida subspecies multocida. Western blot analysis of culture filtrates of the bovine strains revealed a protein, with the same molecular weight as dermonecrotic toxin, which reacted with both polyclonal and monoclonal antibodies against the toxin. In an immunodiffusion test, anti-dermonecrotic toxin serum did not discriminate between the toxin of the bovine strains and the toxin of P multocida subspecies multocida. It is concluded that these atypical pasteurella strains produce a toxin that is closely related to the dermonecrotic toxin of P multocida subspecies multocida.
- Subjects :
- Animals
Blotting, Western
Cattle
Dermotoxins biosynthesis
Enzyme-Linked Immunosorbent Assay
Guinea Pigs
Immunodiffusion
Mice
Pasteurella classification
Pasteurella Infections microbiology
Phenotype
Rhinitis, Atrophic microbiology
Skin Tests
Bacterial Toxins biosynthesis
Cattle Diseases microbiology
Pasteurella metabolism
Pasteurella Infections veterinary
Rhinitis, Atrophic veterinary
Subjects
Details
- Language :
- English
- ISSN :
- 0042-4900
- Volume :
- 126
- Issue :
- 17
- Database :
- MEDLINE
- Journal :
- The Veterinary record
- Publication Type :
- Academic Journal
- Accession number :
- 2111955