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Immunoregulatory effect of a synthetic peptide corresponding to a region of protein p24 of HIV.
Immunoregulatory effect of a synthetic peptide corresponding to a region of protein p24 of HIV.
- Source :
-
Folia biologica [Folia Biol (Praha)] 1990; Vol. 36 (1), pp. 71-7. - Publication Year :
- 1990
-
Abstract
- The effect of a synthetic peptide, corresponding to a sequence of HIV-1 p24 protein (amino acids 218-237), on in vitro immune responses was studied. The peptide inhibited in a dose-dependent manner the induction of an anti-SRC antibody response and of a PPD-specific proliferative response of human PBL. On the other hand, PHA-induced proliferation of human PBL and PPD-induced proliferation of a PPD-specific human T-cell line were not modified by comparable amounts of the peptide. These results suggest that structures from a protein (p24), present in the serum throughout the course of HIV infection, are able to interfere with the inductive stages of specific immune responses. These findings may help to unravel some of the pathogenic mechanisms of AIDS and may contribute to the development of vaccine strategies.
- Subjects :
- Animals
Antibody Formation drug effects
Cell Line
Erythrocytes immunology
Gene Products, gag chemical synthesis
HIV Core Protein p24
Humans
In Vitro Techniques
Lymphocyte Activation drug effects
Lymphocyte Activation immunology
Peptide Fragments chemical synthesis
Phytohemagglutinins immunology
Sheep
T-Lymphocytes immunology
Viral Core Proteins chemical synthesis
Gene Products, gag pharmacology
Immunity drug effects
Lymphocytes immunology
Peptide Fragments pharmacology
Viral Core Proteins pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0015-5500
- Volume :
- 36
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Folia biologica
- Publication Type :
- Academic Journal
- Accession number :
- 2111780