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Dyslipidemia is a strong predictor of myocardial infarction in subjects with chronic kidney disease.
- Source :
-
Annals of medicine [Ann Med] 2012 May; Vol. 44 (3), pp. 262-70. Date of Electronic Publication: 2010 Nov 30. - Publication Year :
- 2012
-
Abstract
- Aim: To evaluate dyslipidemia as predictor of myocardial infarction (MI) in subjects with or without chronic kidney disease (CKD).<br />Methods: In 142,394 middle-aged Swedes referred for laboratory evaluation, glomerular filtration rates (GFR) were estimated using the Modification of Diet in Renal Disease study equation. CKD was defined as GFR 15-60 mL/min/1.73 m(2). Subjects were stratified into presence or absence of CKD, and lipid measures were related to MI using Cox's proportional hazards regression.<br />Results: During 12 years of follow-up there were 5,466 MIs. The adjusted hazard ratio for MI for the highest versus the lowest quartile of the apolipoprotein (apo) B/apoA-1 ratio among individuals without CKD was 2.88 (95% confidence interval 2.54-3.26) and for those with CKD 3.35 (2.25-4.91). The corresponding estimates for the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio were 3.13 (2.78-3.52) and 3.54 (2.43-5.17), respectively. Receiver operator characteristics analyses showed an advantage in the prediction of MI for the apoB/apoA-1 ratio as compared to conventional lipids (P < 0.0001).<br />Conclusions: The ratio of apoB/apoA-1, the ratio of total cholesterol/HDL cholesterol, and non-HDL cholesterol were all strong predictors of myocardial infarction, both among subjects with and without renal dysfunction, with a possible advantage for the apoB/apoA-1 ratio.
- Subjects :
- Adult
Female
Follow-Up Studies
Glomerular Filtration Rate
Humans
Incidence
Kidney Failure, Chronic blood
Kidney Failure, Chronic physiopathology
Male
Middle Aged
Myocardial Infarction epidemiology
Proportional Hazards Models
ROC Curve
Risk Factors
Apolipoproteins blood
Cholesterol blood
Dyslipidemias complications
Kidney Failure, Chronic complications
Myocardial Infarction etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1365-2060
- Volume :
- 44
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Annals of medicine
- Publication Type :
- Academic Journal
- Accession number :
- 21114460
- Full Text :
- https://doi.org/10.3109/07853890.2010.532153