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Activity of some enzymes in the liver of experimental animals after treatment with the liposomal formulation of tetracycline and streptomycin.
- Source :
-
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2010 Jul; Vol. 149 (1), pp. 47-9. - Publication Year :
- 2010
-
Abstract
- A new method for obtaining the liposomal formulation of streptomycin and tetracycline is described in the present work. The physicochemical properties of this formulation were evaluated. We compared the effects of free and liposomal formulations from streptomycin and tetracycline on activity of liver enzymes in albino mice. Immobilization of antibiotics in liposomes was followed by a decrease in the inhibitory effect on protease, alkaline phosphatase, and phosphorylase. The influence of this preparation on ATPase was reduced by 2 times.
- Subjects :
- Alkaline Phosphatase antagonists & inhibitors
Animals
Liver drug effects
Mice
Phosphorylases antagonists & inhibitors
Alkaline Phosphatase metabolism
Liposomes metabolism
Liver enzymology
Phosphorylases metabolism
Protease Inhibitors metabolism
Streptomycin pharmacology
Tetracycline pharmacology
Subjects
Details
- Language :
- English; Russian
- ISSN :
- 1573-8221
- Volume :
- 149
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Bulletin of experimental biology and medicine
- Publication Type :
- Academic Journal
- Accession number :
- 21113456
- Full Text :
- https://doi.org/10.1007/s10517-010-0872-9