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[Sodium-glucose cotransporter type 2 inhibitors (SGLT2): from familial renal glucosuria to the treatment of type 2 diabetes mellitus].
- Source :
-
Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia [Nefrologia] 2010; Vol. 30 (6), pp. 618-25. - Publication Year :
- 2010
-
Abstract
- For centuries, the kidney has been considered primarily an organ of elimination and a regulator of salt and ion balance. Although once thought that the kidney was the structural cause of diabetes, which in recent years has been ignored as a regulator of glucose homeostasis, is now recognized as a major player in the field of metabolic regulation carbohydrate. During fasting, 55% of the glucose comes from gluconeogenesis. Only 2 organs have this capability: the liver and kidney. The latter is responsible for 20% of total glucose production and 40% of that produced by gluconeogenesis. Today we have a better understanding of the physiology of renal glucose transport via specific transporters, such as type 2 sodium-glucose cotransporter  (SGLT2). A natural compound, phlorizin, was isolated in early 1800 and for decades played an important role in diabetes and renal physiology research. Finally, at the nexus of these findings mentioned above, recognized the effect of phlorizin-like compounds in the renal glucose transporter, which has offered a new mechanism to treat hyperglycemia. This has led to the development of several potentially effective treatment modalities for the treatment of diabetes.
- Subjects :
- Absorption
Animals
Benzhydryl Compounds
Diabetes Mellitus, Experimental drug therapy
Diabetes Mellitus, Type 2 metabolism
Dogs
Double-Blind Method
Gluconeogenesis drug effects
Glucose metabolism
Glucosides adverse effects
Glucosides pharmacology
Glycosuria, Renal genetics
Glycosuria, Renal metabolism
Homeostasis
Humans
Hypoglycemic Agents pharmacology
Kidney metabolism
Kidney physiopathology
Kidney Tubules, Proximal metabolism
Mice
Phlorhizin adverse effects
Phlorhizin pharmacokinetics
Phlorhizin pharmacology
Phlorhizin therapeutic use
Randomized Controlled Trials as Topic
Sodium-Glucose Transporter 1 physiology
Sodium-Glucose Transporter 2 genetics
Sodium-Glucose Transporter 2 physiology
Diabetes Mellitus, Type 2 drug therapy
Glucosides therapeutic use
Glycosuria, Renal drug therapy
Hypoglycemic Agents therapeutic use
Sodium-Glucose Transporter 2 Inhibitors
Subjects
Details
- Language :
- Spanish; Castilian
- ISSN :
- 0211-6995
- Volume :
- 30
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia
- Publication Type :
- Academic Journal
- Accession number :
- 21113210
- Full Text :
- https://doi.org/10.3265/Nefrologia.pre2010.Sep.10494