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The anti-ischemic and anti-anginal properties of statins.
- Source :
-
Current atherosclerosis reports [Curr Atheroscler Rep] 2011 Feb; Vol. 13 (1), pp. 43-50. - Publication Year :
- 2011
-
Abstract
- Angina pectoris resulting from myocardial ischemia afflicts half of all patients with coronary heart disease (CHD). Chronic angina remains a major public health burden despite state-of-the-art therapies, and improvement in survival from myocardial infarction and CHD has only increased its prevalence. There is growing experimental and clinical evidence pointing to the anti-ischemic and anti-anginal properties of statins. Some data suggest that the degree of anti-ischemic efficacy of statins may be comparable to the current standard pharmacologic and mechanical strategies. The pleiotropic effects of statins are postulated to be primarily responsible for their anti-ischemic and anti-anginal properties. These include improvement of endothelial function, enhancement of the ischemic vasodilatory response, modulation of inflammation, and protection from ischemia-reperfusion injury. The anti-ischemic effects of statins further strengthen their role as a crucial component of the optimal medical therapy for CHD.
- Subjects :
- Angina Pectoris etiology
Angina Pectoris metabolism
Angina Pectoris physiopathology
Animals
Clinical Trials as Topic
Coronary Vessels drug effects
Coronary Vessels pathology
Endothelium, Vascular metabolism
Endothelium, Vascular physiopathology
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors administration & dosage
Hydroxymethylglutaryl-CoA Reductase Inhibitors adverse effects
Inflammation metabolism
Lipoproteins, LDL metabolism
Myocardial Ischemia complications
Myocardial Ischemia metabolism
Myocardial Ischemia physiopathology
Plaque, Atherosclerotic metabolism
Plaque, Atherosclerotic physiopathology
Reperfusion Injury etiology
Reperfusion Injury metabolism
Reperfusion Injury physiopathology
Treatment Outcome
Vasodilation drug effects
Angina Pectoris drug therapy
Endothelium, Vascular drug effects
Inflammation drug therapy
Myocardial Ischemia drug therapy
Plaque, Atherosclerotic drug therapy
Reperfusion Injury prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 1534-6242
- Volume :
- 13
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Current atherosclerosis reports
- Publication Type :
- Academic Journal
- Accession number :
- 21107759
- Full Text :
- https://doi.org/10.1007/s11883-010-0147-y