Back to Search
Start Over
SNPs on chromosome 5p15.3 associated with myocardial infarction in Japanese population.
- Source :
-
Journal of human genetics [J Hum Genet] 2011 Jan; Vol. 56 (1), pp. 47-51. Date of Electronic Publication: 2010 Nov 25. - Publication Year :
- 2011
-
Abstract
- Myocardial infarction (MI) occurs as the result of complex interactions of multiple genetic and environmental factors. By conducting a genome wide association study in a Japanese population using 210,785 single nucleotide polymorphism (SNP) markers, we identified a novel susceptible locus for MI on chromosome 5p15.3. An SNP (rs11748327) in this locus showed significant association in several independent cohorts (combined P = 5.3 × 10(-13), odds ratio = 0.80, comparison of allele frequency). Association study using tag SNPs in the same linkage disequilibrium block revealed that two additional SNPs (rs490556 and rs521660) conferred risk of MI. These findings indicate that the SNPs on chromosome 5p15.3 are novel protective genetic factors against MI.
- Subjects :
- Algorithms
Female
Gene Frequency
Genetic Predisposition to Disease
Genetics, Population
Genome-Wide Association Study
Genotype
Humans
Linkage Disequilibrium
Male
Validation Studies as Topic
Asian People genetics
Chromosomes, Human, Pair 5 genetics
Myocardial Infarction genetics
Polymorphism, Single Nucleotide
Subjects
Details
- Language :
- English
- ISSN :
- 1435-232X
- Volume :
- 56
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of human genetics
- Publication Type :
- Academic Journal
- Accession number :
- 21107343
- Full Text :
- https://doi.org/10.1038/jhg.2010.141