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Maternal dietary patterns during early pregnancy and the odds of childhood germ cell tumors: A Children's Oncology Group study.
- Source :
-
American journal of epidemiology [Am J Epidemiol] 2011 Feb 01; Vol. 173 (3), pp. 282-91. Date of Electronic Publication: 2010 Nov 23. - Publication Year :
- 2011
-
Abstract
- Maternal diet during pregnancy may be associated with cancer in offspring. Intake of individual foods, as well as dietary patterns, can be used when examining these relations. Here, the authors examined associations between maternal dietary intake patterns and pediatric germ cell tumors (GCTs) using principal components analysis and logistic regression. Mothers of 222 GCT cases aged less than 15 years who were diagnosed at a Children's Oncology Group institution between 1993 and 2001 and those of 336 frequency-matched controls completed a self-administered food frequency questionnaire of diet during early pregnancy. Four dietary patterns were identified: "Western," "fruits and vegetables," "protein," and "healthful." With adjustment for birth weight, parity, and vitamin use, the fruits and vegetables pattern was significantly associated with a lower odds for GCTs (odds ratio (OR) = 0.83, 95% confidence interval (CI): 0.69, 0.99; 2 sided). Upon stratification, the fruits and vegetables pattern was significantly associated with a lower odds in males (OR = 0.66, 95% CI: 0.47, 0.92) but not females (OR = 0.91, 95% CI: 0.72, 1.14). A quantitative assessment of assumed nondifferential reporting error indicated no notable deviations from unadjusted odds ratio estimates. Results of this exploratory analysis suggest that maternal prenatal dietary patterns could be considered in future studies of GCTs in offspring.
- Subjects :
- Adolescent
Case-Control Studies
Child
Child, Preschool
Eating
Female
Fruit
Humans
Infant
Infant, Newborn
Logistic Models
Male
Maternal Behavior
Neoplasms, Germ Cell and Embryonal embryology
Neoplasms, Germ Cell and Embryonal pathology
Odds Ratio
Pregnancy
Risk Factors
Sex Factors
Surveys and Questionnaires
United States epidemiology
Vegetables
Diet adverse effects
Neoplasms, Germ Cell and Embryonal etiology
Neoplasms, Germ Cell and Embryonal prevention & control
Prenatal Exposure Delayed Effects epidemiology
Prenatal Nutritional Physiological Phenomena
Subjects
Details
- Language :
- English
- ISSN :
- 1476-6256
- Volume :
- 173
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- American journal of epidemiology
- Publication Type :
- Academic Journal
- Accession number :
- 21098631
- Full Text :
- https://doi.org/10.1093/aje/kwq365